EC Number | Application | Comment | Organism |
---|---|---|---|
1.5.1.6 | medicine | formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.5.1.6 | cloning and sequencing of the cDNA encoding FDH from fetal liver | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.5.1.6 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.5.1.6 | 98700 | - |
x * 98700, protein with 902 amino acids, calculated from cDNA | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | Homo sapiens | enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.6 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.5.1.6 | additional information | protein with conserved potential N-glycosylation sites, protein kinase phosphorylation sites, and N-myristoylation sites, post-translational modification may be important for the function | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.6 | kidney | mainly expressed in | Homo sapiens | - |
1.5.1.6 | liver | mainly expressed in fetal liver | Homo sapiens | - |
1.5.1.6 | muscle | mainly expressed in skeletal muscle | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | Cys-707 is involved in enzyme activity | Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | enzyme is an important factor in regulation of formate oxidation and is related with methanol poisoning | Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.5.1.6 | ? | x * 98700, protein with 902 amino acids, calculated from cDNA | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Homo sapiens | |
1.5.1.6 | NADP+ | - |
Homo sapiens | |
1.5.1.6 | tetrahydrofolate | - |
Homo sapiens |