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Literature summary extracted from
- The activities of the NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells are kinetically independent (1988), J. Biol. Chem., 263, 4662-4667.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.1.15 | phosphate | requires phosphate anions for stability | Mus musculus |  |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.5.1.15 | requires phosphate anions for stability | Mus musculus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.1.15 | Mg2+ | - |
Mus musculus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.5.1.15 | 34000 | - |
- |
Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.1.15 | L-5,10-methenyl-tetrahydrofolate + NADH | Mus musculus | - |
L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
| 1.5.1.15 | L-5,10-methylenetetrahydrofolate + NAD+ | Mus musculus | - |
5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.5.1.15 | Mus musculus | - |
mouse, Ehrlich ascites tumor cells | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.5.1.15 | - |
Mus musculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.1.15 | L-5,10-methenyl-tetrahydrofolate + NADH | - |
Mus musculus | L-5,10-methylenetetrahydrofolate + NAD+ | - |
r | |
| 1.5.1.15 | L-5,10-methylenetetrahydrofolate + NAD+ | - |
Mus musculus | 5,10-methenyl-tetrahydrofolate + NADH | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.5.1.15 | dimer | 2 * 34000, native bifunctional enzyme, associated with cyclohydrolase, SDS-PAGE | Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.5.1.15 | methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase | - |
Mus musculus |
| 1.5.1.15 | Mg2+/NAD-dependent methylenetetrahydrofolate dehydrogenase | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.1.15 | NAD+ | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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