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Literature summary extracted from

  • Herzfeld, A.; Mezl, V.A.; Knox, W.E.
    Enzymes metabolizing delta1-pyrroline-5-carboxylate in rat tissues (1977), Biochem. J., 166, 95-103.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.88 L-5-oxoproline
-
 Rattus norvegicus
1.2.1.88 L-hydroxyproline
-
 Rattus norvegicus
1.2.1.88 N-ethylmaleimide
-
 Rattus norvegicus
1.2.1.88 p-hydroxymercuribenzoate
-
 Rattus norvegicus
1.5.1.2 NAD+
-
 Rattus norvegicus
1.5.1.2 proline
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.88 0.18
-
 1-pyrroline-5-carboxylate
-
 Rattus norvegicus
1.5.1.2 0.58
-
 NADH
-
 Rattus norvegicus
1.5.1.2 0.62
-
 DL-pyrroline-5-carboxylate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.2 soluble
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.88 Rattus norvegicus
-
-
-
1.5.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.88 kidney
-
 Rattus norvegicus
-
1.2.1.88 liver
-
 Rattus norvegicus
-
1.2.1.88 additional information distribution in rat tissues Rattus norvegicus
-
1.5.1.2 additional information distribution in fetal and tumor tissues Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.88 1-pyrroline-5-carboxylate + NAD+ + H2O
-
 Rattus norvegicus L-glutamate + NADH
-
 ir
1.2.1.88 1-pyrroline-5-carboxylate + NAD+ + H2O
-
 Rattus norvegicus L-glutamate + NADH + H+
-
 r
1.2.1.88 additional information not: glyceraldehyde, valeraldehyde Rattus norvegicus ?
-
 ?
1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ specific for L-isomer Rattus norvegicus L-proline + NAD(P)+
-
 ir
1.5.1.2 L-Pro + NAD+
-
 Rattus norvegicus 1-pyrroline-5-carboxylate + NADH
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.5.1.2
-
-
 complete inactivation after 30 min Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.88 6.7 7.7
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.88 NAD+ preferentially Rattus norvegicus
1.5.1.2 NADH preferentially Rattus norvegicus
1.5.1.2 NADPH
-
 Rattus norvegicus