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Literature summary extracted from

  • Levene, C.I.; Carrington, M.J.
    The inhibition of protein-lysine 6-oxidase by various lathyrogens. Evidence for two different mechanisms (1985), Biochem. J., 232, 293-296.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.3.13 pyridoxal derivative Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 beta-aminopropionitrile lathyrogen, organic nitrile group, blocks active site irreversibly and binds covalently Gallus gallus
1.4.3.13 Isonicotinic acid hydrazide lathyrogen, hydrazide group Gallus gallus
1.4.3.13 Semicarbazide lathyrogen, ureide group Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.13 Cu2+
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.13 collagen + H2O + O2 Gallus gallus
-
 allysyl-collagen + NH3 + H2O2
-
 ?
1.4.3.13 elastin + H2O + O2 Gallus gallus
-
 allysyl-elastin + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Gallus gallus
-
 embryo
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.13 aorta
-
 Gallus gallus
-
1.4.3.13 bone leg Gallus gallus
-
1.4.3.13 cartilage
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.13 collagen + H2O + O2
-
 Gallus gallus allysyl-collagen + NH3 + H2O2
-
 ?
1.4.3.13 elastin + H2O + O2
-
 Gallus gallus allysyl-elastin + NH3 + H2O2
-
 ?
1.4.3.13 peptidyl-L-hydroxylysyl-peptide + O2 + H2O
-
 Gallus gallus peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
 ?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Gallus gallus peptidyl-L-allysyl-peptide + NH3 + H2O2
-
 ?