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Literature summary extracted from

  • Cirilli, M.; Scapin, G.; Sutherland, A.; Vederas, J.C.; Blanchard, J.S.
    The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate (2000), Protein Sci., 9, 2034-2037.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.1.16 crystals of the ternary complex formed from the enzyme, NADP+ and the inhibitor L-2-amino-6-methylene-pimelate, 2.1 A resolution Corynebacterium glutamicum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.16 L-2-amino-6-methylene-pimelate competitive inhibition Lysinibacillus sphaericus

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.16 Corynebacterium glutamicum
-
-
-
1.4.1.16 Lysinibacillus sphaericus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
 Lysinibacillus sphaericus meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
 r
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
 Corynebacterium glutamicum meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.16 NADPH
-
 Lysinibacillus sphaericus
1.4.1.16 NADPH
-
 Corynebacterium glutamicum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.1.16 0.005
-
 L-2-amino-6-methylene-pimelate
-
 Lysinibacillus sphaericus