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Literature summary extracted from

  • Buergi, W.; Richterich, R.; Colombo, J.P.
    L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance (1966), Nature, 211, 854-855.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.1.15 L-lysine + NAD+ Homo sapiens
-
 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.1.15 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.1.15 additional information
-
 11.96 micromol/min*l homogenate, in the presence of cysteine Homo sapiens
1.4.1.15 additional information
-
 6.24 micromol/min*l homogenate, in the absence of cysteine Homo sapiens
1.4.1.15 additional information
-
 2.70 micromol/min*l homogenate, 3 months old baby girl with congenital lysine intolerance, in the presence of cysteine Homo sapiens
1.4.1.15 additional information
-
 0.874 micromol/min*l homogenate, 3 months old baby girl with congenital lysine intolerance, in the absence of cysteine Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.15 L-lysine + NAD+
-
 Homo sapiens 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.15 NAD+
-
 Homo sapiens