Literature summary extracted from

Arnould, S.; Berthon, J.L.; Hubert, C.; Dias, M.; Cibert, C.; Mornet, R.; Camadro, J.M.
Kinetics of protoporphyrinogen oxidase inhibition by diphenyleneiodonium derivatives (1997), Biochemistry, 36, 10178-10184.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.3.3.4	diphenylene iodonium	competitive with respect to oxygen, strongly pH dependent, maximal at pH 8, inhibition by derivatives	Saccharomyces cerevisiae

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.3.3.4	mitochondrion	membrane bound	Saccharomyces cerevisiae	5739	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.3.3.4	protoporphyrinogen-IX + 3 O2	Saccharomyces cerevisiae	penultimate step of heme and chlorophyll biosynthesis	protoporphyrin-IX + 3 H2O2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.3.4	Saccharomyces cerevisiae	-	-	-

Storage Stability

EC Number	Storage Stability	Organism
1.3.3.4	-80°C, 0.1 M phosphate buffer, 1 mM EDTA, 1 mM dithiothreitol, 0.07 mg/ml phenylmethylsulfonyl fluoride, months, no loss of activity	Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.3.4	protoporphyrinogen-IX + 3 O2	-	Saccharomyces cerevisiae	protoporphyrin-IX + 3 H2O2	-	?
1.3.3.4	protoporphyrinogen-IX + 3 O2	penultimate step of heme and chlorophyll biosynthesis	Saccharomyces cerevisiae	protoporphyrin-IX + 3 H2O2	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.3.3.4	0.00007	-	diphenylebeiodonium	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)