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Literature summary extracted from

  • Ferreira, G.C.; Dailey, H.A.
    Mouse protoporphyrinogen oxidase. Kinetic parameters and demonstration of inhibition by bilirubin (1988), Biochem. J., 250, 597-603.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.3.4 dicoumarol below 0.015 mM Mus musculus
1.3.3.4 Ubiquinone-10 below 0.015 mM Mus musculus
1.3.3.4 ubiquinone-6 below 0.015 mM Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.4 bilirubin competitive Mus musculus
1.3.3.4 coenzyme Q0 above 0.03 mM Mus musculus
1.3.3.4 dicoumarol above 0.03 mM Mus musculus
1.3.3.4 menadione above 0.03 mM Mus musculus
1.3.3.4 Ubiquinone-10 above 0.03 mM Mus musculus
1.3.3.4 ubiquinone-6 above 0.03 mM Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.4 0.0066
-
 protoporphyrinogen-IX
-
 Mus musculus
1.3.3.4 0.125
-
 O2
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.4 mitochondrion lipid bilayer of inner membrane Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.4 protoporphyrinogen-IX + 3 O2 Mus musculus penultimate step of heme and chlorophyll biosynthesis protoporphyrin-IX + 3 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.4 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.4
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.4 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.4 protoporphyrinogen-IX + 3 O2
-
 Mus musculus protoporphyrin-IX + 3 H2O2
-
 ?
1.3.3.4 protoporphyrinogen-IX + 3 O2 penultimate step of heme and chlorophyll biosynthesis Mus musculus protoporphyrin-IX + 3 H2O2
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.3.4 0.124
-
 protoporphyrinogen-IX
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.3.4 0.025
-
 bilirubin
-
 Mus musculus