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Literature summary extracted from

  • Besteiro, S.; Biran, M.; Biteau, N.; Coustou, V.; Baltz, T.; Canioni, P.; Bringaud, F.
    Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme: NADH-dependent fumarate reductase (2002), J. Biol. Chem., 22, 38001-38012.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.6 delta FDRg2, fumarate reductase deficiency mutant Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.6 glyoxysome soluble at high ionic strength Trypanosoma brucei 9514
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.6 120000
-
-
 Trypanosoma brucei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.6 fumarate + NADH + H+ Trypanosoma brucei involved in energy metabolism by maintaining the NAD+/NADH balance in glyoxysomes, main source of succinate production succinate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.6 Trypanosoma brucei Q8ITL2
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.6 0.142
-
 glyoxysomal fraction Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.6 fumarate + NADH + H+
-
 Trypanosoma brucei succinate + NAD+
-
 ?
1.3.1.6 fumarate + NADH + H+ involved in energy metabolism by maintaining the NAD+/NADH balance in glyoxysomes, main source of succinate production Trypanosoma brucei succinate + NAD+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.6 NADH
-
 Trypanosoma brucei