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Literature summary extracted from

  • McGuire, J.S.; Hollis, V.W.; Tomkins, G.M.
    Some characteristics of the microsomal steroid reductase (5alpha) of rat liver (1960), J. Biol. Chem., 235, 3112-3117.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 11-ketoprogesterone complete inhibition Rattus norvegicus
1.3.1.22 17beta-hydroxyandrosta-1,4-dien-3-one 50% inhibition Rattus norvegicus
1.3.1.22 19-norandrost-4-ene-3,17-dione complete inhibition Rattus norvegicus
1.3.1.22 19-nortestosterone complete inhibition Rattus norvegicus
1.3.1.22 5alpha-androstane-3,17-dione 30% inhibition Rattus norvegicus
1.3.1.22 6alpha-methyl-11-ketoprogesterone 25% inhibition Rattus norvegicus
1.3.1.22 6beta-methyl-11-ketoprogesterone 50% inhibition Rattus norvegicus
1.3.1.22 androst-1-ene-3,17dione 55% inhibition Rattus norvegicus
1.3.1.22 androst-4-ene-3,17-dione complete inhibition Rattus norvegicus
1.3.1.22 progesterone complete inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.14
-
 cortisone
-
 Rattus norvegicus
1.3.1.22 0.53
-
 NADPH
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 17alpha,21-dihydroxypregn-4-ene-3,11,20-trione + NADPH trivial name cortisone Rattus norvegicus 17alpha,21-dihydroxy-5alpha-pregnan-3,11,20-trione + NADP+
-
 ir
1.3.1.22 17alpha,21-dihydroxypregn-4-ene-3,20-dione + NADPH
-
 Rattus norvegicus 17alpha,21-dihydroxy-5alpha-pregnane-3,20-dione
-
 ?
1.3.1.22 17beta-methyl-androsta-4,9-dien-3-one + NADPH
-
 Rattus norvegicus 17beta-methyl-5alpha-androst-9-en-3-one + NADP+
-
 ?
1.3.1.22 21-hydroxypregn-4-ene-3,20-dione + NADPH
-
 Rattus norvegicus 21-hydroxy-5alpha-pregnan-3,20-dione + NADP+
-
 ?
1.3.1.22 testosterone + NADPH + H+
-
 Rattus norvegicus androstan-3alpha,17beta-diol + androstan-3beta,17beta-diol + 5alpha-dihydrotestosterone
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 5.5 7.5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.22 0.146
-
 17beta-hydroxyandrosta-1,4-diene-3-one
-
 Rattus norvegicus