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Literature summary extracted from

  • Campbell, J.S.; Karavolas, H.J.
    The kinetic mechanism of the hypothalamic progesterone 5alpha-reductase (1989), J. Steroid Biochem., 32, 283-289.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 4-Aza-4-methyl-5alpha-pregnane-3,20-dione
-
 Rattus norvegicus
1.3.1.22 NADP+ product inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.000095
-
 progesterone
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
 female rat
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.1.22 a 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-DELTA4-steroid + NADPH + H+ sequential mechanism Rattus norvegicus
a
1.3.1.22 a 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-DELTA4-steroid + NADPH + H+ kinetic mechanism Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 hypothalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 progesterone + NADPH + H+
-
 Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.22 0.0000062
-
 4-Aza-4-methyl-5alpha-pregnane-3,20-dione versus progesterone Rattus norvegicus
1.3.1.22 0.0000118
-
 4-Aza-4-methyl-5alpha-pregnane-3,20-dione versus NADPH Rattus norvegicus
1.3.1.22 0.0043
-
 NADP+ versus NADPH Rattus norvegicus
1.3.1.22 0.0319
-
 NADP+ versus progesterone Rattus norvegicus