Literature summary extracted from

Metcalf, B.W.; Holt, D.A.; Levy, M.A.; Erb, J.M.; Heaslip, J.I.; Brandt, M.; Oh, H.J.
Potent inhibition of human steroid 5alpha-reductase (EC 1.3.1.30) by 3-androstene-3-carboxylic acids (1989), Bioorg. Chem., 17, 372-376.

No PubMed abstract available

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.3.1.22	17-diisopropylcarbamoyl-2-androsten-3-carboxylate	-	Homo sapiens
1.3.1.22	17-diisopropylcarbamoyl-3,5-androstadien-3-carboxylate	-	Homo sapiens
1.3.1.22	17-diisopropylcarbamoyl-3-androsten-3-carboxyate	-	Homo sapiens
1.3.1.22	17-diisopropylcarbamoyl-androstan-3-carboxylate	-	Homo sapiens
1.3.1.22	17-tert-butylcarbamoyl-3,5-androstadien-3-carbaldehyde	-	Homo sapiens
1.3.1.22	17-tert-butylcarbamoyl-3,5-androstadien-3-carboxylate	dead-end inhibition versus testosterone	Homo sapiens
1.3.1.22	17-tert-butylcarbamoyl-3,5-androstadien-3-ol	-	Homo sapiens
1.3.1.22	3-Androstene-3-carboxylic acids	-	Homo sapiens
1.3.1.22	4-azasteroids	competitive inhibition	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.3.1.22	0.0045	-	testosterone	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.1.22	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.1.22	prostate gland	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.1.22	progesterone + NADPH + H+	-	Homo sapiens	5alpha-pregnan-3-20-dione + NADP+	-	?
1.3.1.22	testosterone + NADPH + H+	-	Homo sapiens	5alpha-dihydrotestosterone + NADP+	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.3.1.22	NADPH	-	Homo sapiens

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.3.1.22	0.000007	0.000018	17-diisopropylcarbamoyl-3,5-androstadien-3-carboxylate	-	Homo sapiens
1.3.1.22	0.00003	-	17-diisopropylcarbamoyl-3-androsten-3-carboxyate	-	Homo sapiens
1.3.1.22	0.000033	-	17-tert-butylcarbamoyl-3,5-androstadien-3-carboxylate	-	Homo sapiens
1.3.1.22	0.000085	-	17-diisopropylcarbamoyl-2-androsten-3-carboxylate	-	Homo sapiens
1.3.1.22	0.0022	-	17-diisopropylcarbamoyl-androstan-3-carboxylate	-	Homo sapiens
1.3.1.22	0.0042	-	17-tert-butylcarbamoyl-3,5-androstadien-3-ol	-	Homo sapiens
1.3.1.22	0.0045	-	17-tert-butylcarbamoyl-3,5-androstadien-3-carbaldehyde	-	Homo sapiens

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Release 2023.1 (January 2023)