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Literature summary extracted from
- Dihydrodipicolinic acid reductase (Escherichia coli) (1971), Methods Enzymol., 17B, 134-139.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.1.8 | additional information | no flavins | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.1.8 | dipicolinate | - |
Escherichia coli |  |
| 1.17.1.8 | isophthalic acid | - |
Escherichia coli | |
| 1.17.1.8 | phosphate | - |
Escherichia coli | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.1.8 | 0.009 | - |
dihydrodipicolinate | - |
Escherichia coli | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.17.1.8 | 110000 | - |
gel filtration, ultracentrifugation | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.1.8 | 2,3-dihydrodipicolinate + NAD(P)H | Escherichia coli | - |
2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.1.8 | Escherichia coli | - |
mutant M-26-26 with 15fold derepression by change to alpha-acetyltrilysine as lysine-providing growth substrate | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.17.1.8 | - |
Escherichia coli |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.17.1.8 | 300 | - |
purified enzyme | Escherichia coli |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.17.1.8 | -20°C, 0.04 M Tris buffer, pH 8.1, precipitate in 65% w/v ammonium sulfate, several months | Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.1.8 | 2,3-dihydrodipicolinate + NAD(P)H | - |
Escherichia coli | 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.1.8 | additional information | - |
additional information | - |
Escherichia coli |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.17.1.8 | 7 | - |
- |
Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.1.8 | additional information | no flavins | Escherichia coli | |
| 1.17.1.8 | NADH | - |
Escherichia coli | |
| 1.17.1.8 | NADPH | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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