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Literature summary extracted from
- Xanthine oxidase and aldehyde oxidase: A simple procedure for the simultaneous purification from rat liver (2002), Arch. Biochem. Biophys., 400, 48-53.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.17.3.2 | the xanthine dehydrogenase form can be obtained through incubation of xanthine oxidase with sulfhydryl reducing reagents | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.17.3.2 | cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.2.3.1 | 300000 | - |
PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.3.1 | additional information | Rattus norvegicus | enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.3.1 | Rattus norvegicus | - |
- |
- |
| 1.17.3.2 | Rattus norvegicus | - |
the xanthine dehydrogenase form can be obtained through incubation of xanthine oxidase with sulphydryl reducing reagents | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.2.3.1 | simultaneous purification with xanthine oxidase | Rattus norvegicus |
| 1.17.3.2 | simultaneous purification of xanthine oxidase and aldehyde oxidase | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.3.1 | liver | - |
Rattus norvegicus | - |
| 1.17.3.2 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.17.3.2 | 3.64 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.3.1 | additional information | enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine | Rattus norvegicus | ? | - |
? | |
| 1.17.3.2 | xanthine + H2O + O2 | - |
Rattus norvegicus | urate + H2O2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.17.3.2 | More | on polyacrylamide gel electrophoresis in presence of SDS and 2-mercaptoethanol the purified xanthine oxidase is dissociated into one major band of approximately 150000 Da and three bands of 100000 Da, 60000 Da and 40000 Da | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.2.3.1 | AO | - |
Rattus norvegicus |
| 1.17.3.2 | XO | - |
Rattus norvegicus |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.17.3.2 | 7.8 | - |
5°C or 10°C, 6 months, no significant loss of activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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