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Literature summary extracted from

  • Fan, D.F.; Oshima, H.; Troen, B.R.; Troen, P.
    Studies of the human testis. IV. Testicular 20alpha-hydroxysteroid dehydrogenase and steroid 17alpha-hydroxylase (1974), Biochim. Biophys. Acta, 360, 88-99.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 pregnenolone
-
 Homo sapiens
1.14.14.19 progesterone
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.19 0.0023
-
 progesterone
-
 Homo sapiens
1.14.14.19 0.0025
-
 pregnenolone
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.19 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2 Homo sapiens
-
 17alpha-hydroxypregnenolone + A + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.19 testis
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
1.14.14.19 -20°C, 0.25 M sucrose, pH 7.4, 2 months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2
-
 Homo sapiens 17alpha-hydroxypregnenolone + A + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.19 6.9 8.5 for 17alpha-hydroxylation of pregnenolone Homo sapiens
1.14.14.19 8.5
-
 for 17alpha-hydroxylation of progesterone Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.19 NADPH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.14.19 0.0008
-
 pregnenolone competitive substrate with progesterone Homo sapiens
1.14.14.19 0.0032
-
 progesterone competitive substrate with pregnenolone Homo sapiens