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Literature summary extracted from

  • Rendina, G.; Singer, T.P.
    Studies on choline dehydrogenase (1959), J. Biol. Chem., 234, 1605-1610.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.1.99.1 25 cycles of freezing/thawing cause 40% loss of activity Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.99.1 7
-
 choline electron acceptor: phenazine methosulfate Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.99.1 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.99.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.99.1 liver
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
1.1.99.1 -15°C, pH 7.4 as mitochondrial acetone powder, 20% loss of activity after 6 days Rattus norvegicus
1.1.99.1 -15°C, pH 7.4 in extracts, 13% loss of activity after 6 days Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.99.1 choline + acceptor acceptor O2: 73% relative activity to phenazine methosulfate Rattus norvegicus betaine aldehyde + reduced acceptor
-
 ?
1.1.99.1 choline + acceptor acceptor 2,6-dichlorophenolindophenol: 27% relative activity to phenazine methosulfate Rattus norvegicus betaine aldehyde + reduced acceptor
-
 ?
1.1.99.1 choline + acceptor cytochrome c, ferricyanide, methylene blue and 2,6-dichlorophenolindophenol show no direct reaction with the enzyme Rattus norvegicus betaine aldehyde + reduced acceptor
-
 ?
1.1.99.1 choline + acceptor acceptor methylene blue: 4% relative activity to phenazine methosulfate Rattus norvegicus betaine aldehyde + reduced acceptor
-
 ?
1.1.99.1 choline + acceptor acceptor cytochrome c: 63% relative activity to phenazine methosulfate Rattus norvegicus betaine aldehyde + reduced acceptor
-
 ?
1.1.99.1 choline + acceptor acceptor: phenazine methosulfate, 100% relative activity Rattus norvegicus betaine aldehyde + reduced acceptor
-
 ?
1.1.99.1 choline + acceptor electron acceptor: phenazine methosulfate Rattus norvegicus betaine aldehyde + reduced acceptor
-
 ?
1.1.99.1 choline + acceptor acceptor ferricyanide: 42% relative activity to phenazine methosulfate Rattus norvegicus betaine aldehyde + reduced acceptor
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.99.1 60
-
 3 min, pH 7, 63% inactivation Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.99.1 7.6 8.2 crude enzyme extract Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.99.1 additional information the enzyme requires no readily dissociable coenzyme for activity Rattus norvegicus