EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.3.15 | 4-chloromercuribenzoate | strong inhibition at 0.01 mM | Rattus sp. | |
1.1.3.15 | 8-hydroxyquinoline | 5-17% inhibition at 1 mM | Rattus sp. | |
1.1.3.15 | Cu2+ | nearly complete inhibition at 0.025 mM | Rattus sp. | |
1.1.3.15 | cysteine | 28-38% inhibition of glycolate oxidation at 1 mM | Rattus sp. | |
1.1.3.15 | diethyldithiocarbamate | competitive inhibition | Rattus sp. | |
1.1.3.15 | diphenylglycolic acid | 11-17% inhibition at 52 mM | Rattus sp. | |
1.1.3.15 | hydoxylamine | 66-67% inhibition at 5 mM | Rattus sp. | |
1.1.3.15 | KCN | mixed-type inhibitor | Rattus sp. | |
1.1.3.15 | o-Iodosobenzoate | 46-62% inhibition at 0.1 mM | Rattus sp. | |
1.1.3.15 | o-phenanthroline | 5-23% inhibition at 1 mM | Rattus sp. | |
1.1.3.15 | oxalate | 18% inhibition of glycolate oxidation, 71% inhibition of glyoxylate oxidation at 0.03 mM | Rattus sp. |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.3.15 | 0.22 | - |
glycolate | cosubstrates: 2,4-dinitrophenyl hydrazone | Rattus sp. | |
1.1.3.15 | 0.24 | - |
glycolate | cosubstrate: O2 | Rattus sp. | |
1.1.3.15 | 1.24 | - |
L-2-Hydroxyisocaproate | cosubstrate: 2,4-dinitrophenyl hydrazone | Rattus sp. | |
1.1.3.15 | 1.26 | - |
L-2-Hydroxyisocaproate | cosubstrate: O2 | Rattus sp. | |
1.1.3.15 | 1.41 | - |
glyoxylate | cosubstrate: O2 | Rattus sp. | |
1.1.3.15 | 1.78 | - |
glyoxylate | cosubstrate: 2,4-dinitrophenyl hydrazone | Rattus sp. |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.3.15 | peroxisome | - |
Rattus sp. | 5777 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.3.15 | D-lactate + O2 | Rattus sp. | traces of activity | pyruvate + H2O2 | - |
? | |
1.1.3.15 | DL-2-hydroxybutyrate + O2 | Rattus sp. | - |
2-oxobutyrate + H2O2 | - |
? | |
1.1.3.15 | DL-2-hydroxyisovalerate + O2 | Rattus sp. | low activity | 2-oxoisovalerate + H2O2 | - |
? | |
1.1.3.15 | glycolate + O2 | Rattus sp. | - |
glyoxylate + H2O2 | - |
? | |
1.1.3.15 | glyoxylate + O2 | Rattus sp. | 40% of the activity compared to glycolate | ? + H2O2 | - |
? | |
1.1.3.15 | L-2-hydroxyisocaproate + O2 | Rattus sp. | - |
2-oxoisocaproate + H2O2 | - |
? | |
1.1.3.15 | L-lactate + O2 | Rattus sp. | very low activity | pyruvate + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.3.15 | Rattus sp. | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.3.15 | partial | Rattus sp. |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.3.15 | liver | - |
Rattus sp. | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.3.15 | 0.28 | - |
- |
Rattus sp. |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.3.15 | D-lactate + O2 | traces of activity | Rattus sp. | pyruvate + H2O2 | - |
? | |
1.1.3.15 | DL-2-hydroxybutyrate + 2,4-dinitrophenylhydrazine | low activity | Rattus sp. | 2-oxobutyrate 2,4-dinitrophenylhydrazone + ? | - |
? | |
1.1.3.15 | DL-2-hydroxybutyrate + O2 | - |
Rattus sp. | 2-oxobutyrate + H2O2 | - |
? | |
1.1.3.15 | DL-2-hydroxyisovalerate + 2,4-dinitrophenylhydrazine | very low activity | Rattus sp. | 2-oxoisovalerate 2,4-dinitrophenylhydrazone + ? | - |
? | |
1.1.3.15 | DL-2-hydroxyisovalerate + O2 | low activity | Rattus sp. | 2-oxoisovalerate + H2O2 | - |
? | |
1.1.3.15 | glycolate + 2,4-dinitrophenylhydrazine | best substrate tested | Rattus sp. | glyoxylate 2,4-dinitrophenylhydrazone + ? | - |
? | |
1.1.3.15 | glycolate + O2 | - |
Rattus sp. | glyoxylate + H2O2 | - |
? | |
1.1.3.15 | glyoxylate + O2 | 40% of the activity compared to glycolate | Rattus sp. | ? + H2O2 | - |
? | |
1.1.3.15 | L-2-hydroxyisocaproate + 2,4-dinitrophenylhydrazine | - |
Rattus sp. | 2-oxoisocaproate 2,4-dinitrophenylhydrazone + ? | - |
? | |
1.1.3.15 | L-2-hydroxyisocaproate + O2 | - |
Rattus sp. | 2-oxoisocaproate + H2O2 | - |
? | |
1.1.3.15 | L-lactate + 2,4-dinitrophenylhydrazine | very low activity | Rattus sp. | pyruvate 2,4-dinitrophenylhydrazone + ? | - |
? | |
1.1.3.15 | L-lactate + O2 | very low activity | Rattus sp. | pyruvate + H2O2 | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.3.15 | 8.5 | - |
- |
Rattus sp. |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.3.15 | FMN | - |
Rattus sp. |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.3.15 | 0.27 | 0.39 | diethyldithiocarbamate | competitive inhibition | Rattus sp. | |
1.1.3.15 | 0.52 | 0.65 | KCN | mixed-type inhibition | Rattus sp. |