Literature summary extracted from

Stolz, A.; Takikawa, H.; Sugiyama, Y.; Kuhlenkamp, J.; Kaplowitz, N.
3alpha-hydroxysteroid dehydrogenase activity of the Y'bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance (1987), J. Clin. Invest., 79, 427-434.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.50	cholic acid	complete inhibition	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.50	cytosol	-	Rattus norvegicus	5829	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.1.1.50	33000	-	gel filtration	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.50	additional information	Rattus norvegicus	belongs to the group of Y'bile acid binders, bile acid metabolizing enzymes	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.50	Rattus norvegicus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.50	three forms I, II, III	Rattus norvegicus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.50	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.50	3-oxocholic acid + NADPH	reverse reaction rate negligible	Rattus norvegicus	3alpha-hydroxycholic acid + NADP+	-	ir
1.1.1.50	additional information	belongs to the group of Y'bile acid binders, bile acid metabolizing enzymes	Rattus norvegicus	?	-	?

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
1.1.1.50	7	-	alpha-HSD I	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.50	NADPH	preference for	Rattus norvegicus

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Release 2023.1 (January 2023)