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Literature summary extracted from

  • Cherradi, N.; Defaye, G.; Chambaz, E.M.
    Characterization of the 3beta-hydroxysteroid dehydrogenase activity associated with bovine adrenocortical mitochondria (1994), Endocrinology, 134, 1358-1364.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.145 0.0016
-
dehydroepiandrosterone microsomes Bos taurus
1.1.1.145 0.002
-
pregnenolone mitochondria Bos taurus
1.1.1.145 0.0032
-
pregnenolone microsomes Bos taurus
1.1.1.145 0.0045
-
dehydroepiandrosterone mitochondria Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.145 mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.145 dehydroepiandrosterone + NAD+ Bos taurus
-
androst-5-en-3,17-dione + NADH + H+
-
?
1.1.1.145 pregnenolone + NAD(P)+ Bos taurus
-
pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.145 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.145 adrenal gland
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.145 0.0043
-
mitochondria Bos taurus
1.1.1.145 0.0158
-
microsomes Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.145 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
Bos taurus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
?
1.1.1.145 dehydroepiandrosterone + NAD+
-
Bos taurus androst-5-en-3,17-dione + NADH + H+
-
?
1.1.1.145 pregnenolone + NAD(P)+
-
Bos taurus pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.145 NAD+
-
Bos taurus