EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.2 | GTP | allosteric inhibition | Drosophila melanogaster | |
5.6.2.2 | GTP-gamma-S | allosteric inhibition | Drosophila melanogaster | |
5.6.2.2 | Z-DNA | inhibits relaxation of closed circular supercoiled DNA | Drosophila melanogaster |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.2.2 | additional information | Drosophila melanogaster | the Z-DNA binding activity of undegraded topoisomerase II may be important in targeting the enzyme both to structural motifs required for chromatin organization and to sites of local supercoiling | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.6.2.2 | Drosophila melanogaster | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.6.2.2 | embryo | - |
Drosophila melanogaster | - |
5.6.2.2 | tissue culture | - |
Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.6.2.2 | additional information | enzyme binds Z-DNA with an affinity 2 orders of magnitude greater than that for B-DNA | Drosophila melanogaster | ? | - |
? | |
5.6.2.2 | additional information | the Z-DNA binding activity of undegraded topoisomerase II may be important in targeting the enzyme both to structural motifs required for chromatin organization and to sites of local supercoiling | Drosophila melanogaster | ? | - |
? | |
5.6.2.2 | network of DNA rings + ATP + H2O | decatenation | Drosophila melanogaster | monomeric DNA circles + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | catenation | Drosophila melanogaster | catenated DNA networks + ADP + phosphate | - |
? | |
5.6.2.2 | supercoiled DNA + ATP + H2O | relaxation | Drosophila melanogaster | relaxed DNA + ADP + phosphate | - |
? |