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Literature summary extracted from

  • Han, L.P.B.; Davison, L.M.; vander Jagt, D.L.
    Purification and kinetic study of glyoxalase-I from rat liver, erythrocytes, brain and kidney (1976), Biochim. Biophys. Acta, 445, 486-499.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.5 0.01
-
 p-methoxyphenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.02
-
 p-chlorophenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.02
-
 p-phenylphenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.02
-
 4-bromophenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.02
-
 4-methylphenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.03
-
 p-hydroxyphenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.03
-
 m-methoxyphenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.04
-
 Phenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.07
-
 2,4-dimethylphenylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.09
-
 methylglyoxal liver or erythrocyte enzyme Rattus norvegicus
4.4.1.5 0.2
-
 kethoxal
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.4.1.5 50000
-
 liver and erythrocyte enzyme, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.4.1.5 (R)-S-lactoylglutathione = glutathione + 2-oxopropanal intramolecular hydride migration is the rate-determining step Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 brain
-
 Rattus norvegicus
-
4.4.1.5 erythrocyte
-
 Rattus norvegicus
-
4.4.1.5 kidney
-
 Rattus norvegicus
-
4.4.1.5 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.4.1.5 191
-
 kidney enzyme Rattus norvegicus
4.4.1.5 814
-
 brain enzyme Rattus norvegicus
4.4.1.5 983
-
 liver enzyme Rattus norvegicus
4.4.1.5 2410
-
-
 Rattus norvegicus
4.4.1.5 2415
-
 erythrocyte enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 glutathione + 2,4-dimethylphenylglyoxal
-
 Rattus norvegicus S-(2,4-dimethyl)mandeloylglutathione
-
 ?
4.4.1.5 glutathione + 4-bromophenylglyoxal
-
 Rattus norvegicus S-(4-bromo)mandeloylglutathione
-
 ?
4.4.1.5 glutathione + 4-methylphenylglyoxal
-
 Rattus norvegicus S-(4-methyl)mandeloylglutathione
-
 ?
4.4.1.5 glutathione + bromophenylglyoxal
-
 Rattus norvegicus ?
-
 ?
4.4.1.5 glutathione + kethoxal
-
 Rattus norvegicus ?
-
 ?
4.4.1.5 glutathione + m-methoxyphenylglyoxal
-
 Rattus norvegicus S-(3-methoxy)mandeloylglutathione
-
 ?
4.4.1.5 glutathione + methylglyoxal
-
 Rattus norvegicus S-lactoylglutathione
-
 ?
4.4.1.5 glutathione + methylphenylglyoxal
-
 Rattus norvegicus ?
-
 ?
4.4.1.5 glutathione + p-chlorophenylglyoxal
-
 Rattus norvegicus S-(4-chloro)mandeloylglutathione
-
 ?
4.4.1.5 glutathione + p-hydroxyphenylglyoxal
-
 Rattus norvegicus S-(4-hydroxy)mandeloylglutathione
-
 ?
4.4.1.5 glutathione + p-methoxyphenylglyoxal
-
 Rattus norvegicus S-(4-methoxy)mandeloylglutathione
-
 ?
4.4.1.5 glutathione + p-phenylphenylglyoxal
-
 Rattus norvegicus ?
-
 ?
4.4.1.5 glutathione + phenylglyoxal
-
 Rattus norvegicus S-mandeloylglutathione
-
 ?