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Literature summary extracted from
- The glyoxalase system (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, 3, 597-641.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.2.6 | 2,4,6-Trinitrobenzenesulfonate | - |
Homo sapiens |  |
| 3.1.2.6 | 2,4,6-Trinitrobenzenesulfonate | - |
Rattus norvegicus | |
| 3.1.2.6 | diethyldicarbonate | - |
Rattus norvegicus | |
| 3.1.2.6 | methylene blue | photoinactivation | Rattus norvegicus | |
| 3.1.2.6 | Phenylglyoxal | - |
Rattus norvegicus | |
| 4.4.1.5 | additional information | - |
Escherichia coli | |
| 4.4.1.5 | additional information | - |
Homo sapiens | |
| 4.4.1.5 | additional information | - |
Mus musculus | |
| 4.4.1.5 | additional information | - |
Oryctolagus cuniculus | |
| 4.4.1.5 | additional information | - |
Ovis aries | |
| 4.4.1.5 | additional information | - |
Rattus norvegicus | |
| 4.4.1.5 | additional information | - |
Rhodospirillum rubrum | |
| 4.4.1.5 | additional information | - |
Saccharomyces cerevisiae | |
| 4.4.1.5 | additional information | - |
Sus scrofa |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.2.6 | 0.016 | - |
S-mandeloylglutathione | enzyme from liver | Homo sapiens | |
| 3.1.2.6 | 0.07 | - |
S-glycolylglutathione | enzyme from liver | Homo sapiens | |
| 3.1.2.6 | 0.109 | - |
S-glyceroylglutathione | enzyme from liver | Homo sapiens | |
| 3.1.2.6 | 0.153 | - |
S-formylglutathione | enzyme from liver | Homo sapiens | |
| 3.1.2.6 | 0.19 | - |
S-Lactoylglutathione | enzyme from liver | Homo sapiens | |
| 3.1.2.6 | 0.2 | - |
S-succinylglutathione | enzyme from liver | Homo sapiens | |
| 3.1.2.6 | 0.213 | - |
S-propionylglutathione | enzyme from liver | Homo sapiens | |
| 3.1.2.6 | 0.266 | - |
S-acetylglutathione | enzyme from liver | Homo sapiens | |
| 3.1.2.6 | 0.295 | - |
S-Acetoacetylglutathione | enzyme from liver | Homo sapiens | |
| 4.4.1.5 | additional information | - |
additional information | - |
Mus musculus | |
| 4.4.1.5 | additional information | - |
additional information | - |
Escherichia coli | |
| 4.4.1.5 | additional information | - |
additional information | - |
Homo sapiens | |
| 4.4.1.5 | additional information | - |
additional information | - |
Rattus norvegicus | |
| 4.4.1.5 | additional information | - |
additional information | - |
Sus scrofa | |
| 4.4.1.5 | additional information | - |
additional information | - |
Saccharomyces cerevisiae | |
| 4.4.1.5 | additional information | - |
additional information | - |
Oryctolagus cuniculus | |
| 4.4.1.5 | additional information | - |
additional information | - |
Ovis aries | |
| 4.4.1.5 | additional information | - |
additional information | - |
Rhodospirillum rubrum | |
| 4.4.1.5 | 0.06 | - |
alpha-deuteriophenylglyoxal | - |
Saccharomyces cerevisiae | |
| 4.4.1.5 | 0.19 | - |
perdeuteriomethylglyoxal | - |
Saccharomyces cerevisiae | |
| 4.4.1.5 | 0.2 | - |
Phenylglyoxal | - |
Saccharomyces cerevisiae | |
| 4.4.1.5 | 0.32 | - |
methylglyoxal | - |
Saccharomyces cerevisiae | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.5 | Zn2+ | zinc metalloenzymes | Homo sapiens | |
| 4.4.1.5 | Zn2+ | zinc metalloenzymes | Rattus norvegicus | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Mus musculus | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Escherichia coli | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Homo sapiens | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Rattus norvegicus | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Sus scrofa | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Saccharomyces cerevisiae | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Oryctolagus cuniculus | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Ovis aries | |
| 4.4.1.5 | Zn2+ | metalloenzyme with one Zn2+ per subunit | Rhodospirillum rubrum | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.5 | 31000 | - |
- |
Rhodospirillum rubrum |
| 4.4.1.5 | 34000 | - |
- |
Escherichia coli |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.2.6 | Homo sapiens | - |
- |
- |
| 3.1.2.6 | Mesocricetus auratus | - |
- |
- |
| 3.1.2.6 | Mus musculus | - |
- |
- |
| 3.1.2.6 | Rattus norvegicus | - |
- |
- |
| 4.4.1.5 | Escherichia coli | - |
- |
- |
| 4.4.1.5 | Homo sapiens | - |
- |
- |
| 4.4.1.5 | Mus musculus | - |
- |
- |
| 4.4.1.5 | Oryctolagus cuniculus | - |
- |
- |
| 4.4.1.5 | Ovis aries | - |
- |
- |
| 4.4.1.5 | Rattus norvegicus | - |
- |
- |
| 4.4.1.5 | Rhodospirillum rubrum | - |
- |
- |
| 4.4.1.5 | Saccharomyces cerevisiae | - |
- |
- |
| 4.4.1.5 | Sus scrofa | - |
- |
- |
Oxidation Stability
| EC Number | Oxidation Stability | Organism |
|---|---|---|
| 3.1.2.6 | photoinactivation by methylene blue | Rattus norvegicus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Mus musculus | |
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Escherichia coli | |
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Homo sapiens | |
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Rattus norvegicus | |
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Sus scrofa | |
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Saccharomyces cerevisiae | |
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Oryctolagus cuniculus | |
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Ovis aries | |
| 4.4.1.5 | (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | mechanism | Rhodospirillum rubrum |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.2.6 | brain | - |
Homo sapiens | - |
| 3.1.2.6 | brain | - |
Rattus norvegicus | - |
| 3.1.2.6 | Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
| 3.1.2.6 | erythrocyte | - |
Homo sapiens | - |
| 3.1.2.6 | erythrocyte | - |
Rattus norvegicus | - |
| 3.1.2.6 | fibroadenoma cell | fibroadenoma mammae cells | Homo sapiens | - |
| 3.1.2.6 | glioblastoma cell | glioblastoma multiform cells | Homo sapiens | - |
| 3.1.2.6 | hepatoma cell | Morris hepatoma cells 5123S | Rattus norvegicus | - |
| 3.1.2.6 | hepatoma cell | Kirkman-Robbins hepatoma | Mesocricetus auratus | - |
| 3.1.2.6 | liver | - |
Mus musculus | - |
| 3.1.2.6 | liver | - |
Homo sapiens | - |
| 3.1.2.6 | liver | - |
Rattus norvegicus | - |
| 3.1.2.6 | muscle | - |
Homo sapiens | - |
| 3.1.2.6 | S-180 cell | - |
Mus musculus | - |
| 4.4.1.5 | adipose tissue | - |
Homo sapiens | - |
| 4.4.1.5 | adrenal gland | - |
Homo sapiens | - |
| 4.4.1.5 | aorta | - |
Homo sapiens | - |
| 4.4.1.5 | brain | - |
Homo sapiens | - |
| 4.4.1.5 | brain | - |
Rattus norvegicus | - |
| 4.4.1.5 | diaphragm | - |
Homo sapiens | - |
| 4.4.1.5 | erythrocyte | - |
Mus musculus | - |
| 4.4.1.5 | erythrocyte | - |
Homo sapiens | - |
| 4.4.1.5 | erythrocyte | - |
Rattus norvegicus | - |
| 4.4.1.5 | erythrocyte | - |
Sus scrofa | - |
| 4.4.1.5 | erythrocyte | - |
Oryctolagus cuniculus | - |
| 4.4.1.5 | erythrocyte | - |
Ovis aries | - |
| 4.4.1.5 | heart | - |
Homo sapiens | - |
| 4.4.1.5 | kidney | - |
Homo sapiens | - |
| 4.4.1.5 | kidney | - |
Rattus norvegicus | - |
| 4.4.1.5 | liver | - |
Mus musculus | - |
| 4.4.1.5 | liver | - |
Homo sapiens | - |
| 4.4.1.5 | liver | - |
Rattus norvegicus | - |
| 4.4.1.5 | liver | - |
Oryctolagus cuniculus | - |
| 4.4.1.5 | liver | - |
Ovis aries | - |
| 4.4.1.5 | lung | - |
Homo sapiens | - |
| 4.4.1.5 | pancreas | - |
Homo sapiens | - |
| 4.4.1.5 | small intestine | - |
Homo sapiens | - |
| 4.4.1.5 | spleen | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.6 | 773 | - |
- |
Rattus norvegicus |
| 3.1.2.6 | 822 | - |
- |
Homo sapiens |
| 3.1.2.6 | 920 | - |
- |
Mus musculus |
| 4.4.1.5 | 565 | - |
- |
Mus musculus |
| 4.4.1.5 | 681 | - |
- |
Oryctolagus cuniculus |
| 4.4.1.5 | 950 | - |
liver | Rattus norvegicus |
| 4.4.1.5 | 957 | - |
- |
Sus scrofa |
| 4.4.1.5 | 2110 | - |
erythrocytes | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.2.6 | lactoylglutathione + H2O | - |
Mus musculus | D-lactate + glutathione | - |
? | |
| 3.1.2.6 | lactoylglutathione + H2O | - |
Homo sapiens | D-lactate + glutathione | - |
? | |
| 3.1.2.6 | lactoylglutathione + H2O | - |
Rattus norvegicus | D-lactate + glutathione | - |
? | |
| 3.1.2.6 | S-acetoacetylglutathione + H2O | - |
Homo sapiens | acetoacetate + glutathione | - |
? | |
| 3.1.2.6 | S-acetoacetylglutathione + H2O | - |
Rattus norvegicus | acetoacetate + glutathione | - |
? | |
| 3.1.2.6 | S-acetylglutathione + H2O | - |
Homo sapiens | acetate + glutathione | - |
? | |
| 3.1.2.6 | S-acetylglutathione + H2O | - |
Rattus norvegicus | acetate + glutathione | - |
? | |
| 3.1.2.6 | S-formylglutathione + H2O | - |
Homo sapiens | formate + glutathione | - |
? | |
| 3.1.2.6 | S-formylglutathione + H2O | - |
Rattus norvegicus | formate + glutathione | - |
? | |
| 3.1.2.6 | S-glyceroylglutathione + H2O | - |
Homo sapiens | glycerate + glutathione | - |
? | |
| 3.1.2.6 | S-glycerylglutathione + H2O | - |
Homo sapiens | glycerate + glutathione | - |
? | |
| 3.1.2.6 | S-glycoloylglutathione + H2O | - |
Homo sapiens | glycolate + glutathione | - |
? | |
| 3.1.2.6 | S-lactoylglutathione + H2O | - |
Homo sapiens | D-lactate + glutathione | - |
? | |
| 3.1.2.6 | S-mandeloylglutathione + H2O | - |
Homo sapiens | mandelate + glutathione | - |
? | |
| 3.1.2.6 | S-propionylglutathione + H2O | - |
Homo sapiens | propionate + glutathione | - |
? | |
| 3.1.2.6 | S-propionylglutathione + H2O | - |
Rattus norvegicus | propionate + glutathione | - |
? | |
| 3.1.2.6 | S-succinylglutathione + H2O | - |
Homo sapiens | succinate + glutathione | - |
? | |
| 3.1.2.6 | S-succinylglutathione + H2O | - |
Rattus norvegicus | succinate + glutathione | - |
? | |
| 4.4.1.5 | glutathione + methylglyoxal | - |
Mus musculus | S-lactoylglutathione | - |
? | |
| 4.4.1.5 | glutathione + methylglyoxal | - |
Escherichia coli | S-lactoylglutathione | - |
? | |
| 4.4.1.5 | glutathione + methylglyoxal | - |
Homo sapiens | S-lactoylglutathione | - |
? | |
| 4.4.1.5 | glutathione + methylglyoxal | - |
Rattus norvegicus | S-lactoylglutathione | - |
? | |
| 4.4.1.5 | glutathione + methylglyoxal | - |
Sus scrofa | S-lactoylglutathione | - |
? | |
| 4.4.1.5 | glutathione + methylglyoxal | - |
Saccharomyces cerevisiae | S-lactoylglutathione | - |
? | |
| 4.4.1.5 | glutathione + methylglyoxal | - |
Ovis aries | S-lactoylglutathione | - |
? | |
| 4.4.1.5 | glutathione + p-chlorophenylglyoxal | - |
Rattus norvegicus | S-(4-chloro)mandeloylglutathione | - |
? | |
| 4.4.1.5 | glutathione + p-chlorophenylglyoxal | - |
Saccharomyces cerevisiae | S-(4-chloro)mandeloylglutathione | - |
? | |
| 4.4.1.5 | glutathione + phenylglyoxal | - |
Saccharomyces cerevisiae | S-mandeloylglutathione | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Mus musculus | ? | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Escherichia coli | ? | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Homo sapiens | ? | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Rattus norvegicus | ? | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Sus scrofa | ? | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Saccharomyces cerevisiae | ? | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Oryctolagus cuniculus | ? | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Ovis aries | ? | - |
? | |
| 4.4.1.5 | additional information | activity with glutathione analogs | Rhodospirillum rubrum | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.6 | 6.8 | 7.5 | - |
Homo sapiens |
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