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Literature summary extracted from

  • Yoshida, H.; Kumagai, H.; Yamada, H.
    Catalytic properties of tryptophanase from Proteus rettgeri (1974), Agric. Biol. Chem., 38, 463-464.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.99.1 Ala D-Ala; L-Ala Providencia rettgeri
4.1.99.1 indole
-
 Providencia rettgeri
4.1.99.1 Phe L-Phe Providencia rettgeri

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.99.1 0.26
-
 L-Trp
-
 Providencia rettgeri
4.1.99.1 1
-
 L-Cys alpha,beta-elimination Providencia rettgeri
4.1.99.1 1.8
-
 5-methyl-L-Trp alpha,beta-elimination Providencia rettgeri
4.1.99.1 2.7
-
 5-hydroxy-L-Trp alpha,beta-elimination Providencia rettgeri
4.1.99.1 2.8
-
 L-Cys beta-replacement reaction Providencia rettgeri
4.1.99.1 3.1
-
 S-methyl-L-Cys beta-replacement reaction Providencia rettgeri
4.1.99.1 4
-
 indole beta-replacement reaction Providencia rettgeri
4.1.99.1 4.1
-
 indole reverse of alpha,beta-elimination Providencia rettgeri
4.1.99.1 5
-
 S-methyl-L-Cys alpha,beta-elimination Providencia rettgeri
4.1.99.1 10
-
 pyruvate cosubstrate indole, alpha,beta-addition Providencia rettgeri

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.1 Providencia rettgeri
-
 AJ2770
-
4.1.99.1 Providencia rettgeri AJ2770
-
 AJ2770
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.1 5-hydroxyindole + L-Cys
-
 Providencia rettgeri 5-hydroxy-L-Trp + ?
-
 ?
4.1.99.1 5-hydroxyindole + S-methyl-L-Cys
-
 Providencia rettgeri 5-hydroxy-L-Trp + ?
-
 ?
4.1.99.1 5-methylindole + L-Cys
-
 Providencia rettgeri 5-methyl-L-Trp + ?
-
 ?
4.1.99.1 5-methylindole + S-methyl-L-Cys
-
 Providencia rettgeri 5-methyl-L-Trp + ?
-
 ?
4.1.99.1 Cys + H2O L-Cys Providencia rettgeri ?
-
 ?
4.1.99.1 Cys + H2O L-Cys Providencia rettgeri AJ2770 ?
-
 ?
4.1.99.1 indole + L-Cys beta-replacement reaction Providencia rettgeri L-Trp + ?
-
 ?
4.1.99.1 indole + L-Cys beta-replacement reaction Providencia rettgeri AJ2770 L-Trp + ?
-
 ?
4.1.99.1 indole + pyruvate + NH4+
-
 Providencia rettgeri L-Trp + H2O
-
 ?
4.1.99.1 indole + pyruvate + NH4+
-
 Providencia rettgeri AJ2770 L-Trp + H2O
-
 ?
4.1.99.1 indole + S-methyl-L-Cys beta-replacement reaction Providencia rettgeri L-Trp + ?
-
 ?
4.1.99.1 indole + S-methyl-L-Cys beta-replacement reaction Providencia rettgeri AJ2770 L-Trp + ?
-
 ?
4.1.99.1 L-Trp + H2O
-
 Providencia rettgeri indole + pyruvate + NH4+
-
 ?
4.1.99.1 S-methyl-L-Cys + H2O
-
 Providencia rettgeri ?
-
 ?
4.1.99.1 S-methyl-L-Cys + H2O
-
 Providencia rettgeri AJ2770 ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.99.1 8.5 9.5 synthesis of L-Trp from indole and L-Cys or S-methyl-L-Cys Providencia rettgeri
4.1.99.1 9
-
 synthesis of L-Trp from indole, NH4+ and pyruvate Providencia rettgeri

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.99.1 pyridoxal 5'-phosphate dependent on Providencia rettgeri