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Literature summary extracted from
- Purification and characterization of three forms of collagenase from Clostridium histolyticum (1984), Biochemistry, 23, 5175-5181.
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.3 | Zn2+ | zinc enzyme, 1.14 mol zinc per mol, enzyme form C1, 0.82 mol zinc per mol enzyme, form C3 | Hathewaya histolytica |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.3 | 76000 | - |
? * 76000, C3, SDS-PAGE | Hathewaya histolytica |
| 3.4.24.3 | 92000 | - |
? * 92000, C2, SDS-PAGE | Hathewaya histolytica |
| 3.4.24.3 | 96000 | - |
? * 96000, C1, SDS-PAGE | Hathewaya histolytica |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.3 | Collagen + H2O | Hathewaya histolytica | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.3 | Hathewaya histolytica | - |
3 forms: C1, C2, C3 differ in molecular weight | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.24.3 | no modification | C1: no carbohydrate | Hathewaya histolytica |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.3 | - |
Hathewaya histolytica |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.3 | Collagen + H2O | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form | Hathewaya histolytica | Hydrolyzed collagen | - |
? | |
| 3.4.24.3 | Collagen + H2O | degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro | Hathewaya histolytica | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.3 | ? | ? * 76000, C3, SDS-PAGE | Hathewaya histolytica |
| 3.4.24.3 | ? | ? * 92000, C2, SDS-PAGE | Hathewaya histolytica |
| 3.4.24.3 | ? | ? * 96000, C1, SDS-PAGE | Hathewaya histolytica |
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