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Literature summary extracted from
- Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes (1986), J. Biol. Chem., 261, 11274-11281.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.16 | 1,10-phenanthroline | 1 mM, 95% inhibition | Rattus norvegicus |  |
| 3.4.24.16 | alpha-melanotrophin-stimulating hormone | weak | Rattus norvegicus | |
| 3.4.24.16 | angiotensin I | - |
Rattus norvegicus | |
| 3.4.24.16 | bombesin | weak | Rattus norvegicus | |
| 3.4.24.16 | carboxyphenylethyl-Ala-Ala-Phe-4-aminobenzoate | 0.001 mM, 30% inhibition | Rattus norvegicus | |
| 3.4.24.16 | EDTA | 1 mM, 51% inhibition | Rattus norvegicus | |
| 3.4.24.16 | Neuromedin N | - |
Rattus norvegicus | |
| 3.4.24.16 | neurotensin(9-13) | the shortest neurotensin partial sequence that is able to fully inhibit neurotensin degradation | Rattus norvegicus | |
| 3.4.24.16 | Somatostatin | weak | Rattus norvegicus | |
| 3.4.24.16 | Substance P | weak | Rattus norvegicus | |
| 3.4.24.16 | Tuftsin | weak | Rattus norvegicus | |
| 3.4.24.16 | Xenopsin | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.16 | 0.0026 | - |
neurotensin | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.16 | membrane | synaptic | Rattus norvegicus | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.16 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.16 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.16 | brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.16 | 0.0226 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.16 | neurotensin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.24.16 | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu + H2O | i.e. neurotensin | Rattus norvegicus | pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro + Tyr-Ile-Leu | - |
? | |
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