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Literature summary extracted from
- The fibrin(ogen)olytic properties of cathepsin D (1994), Biochemistry, 33, 6555-6563.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.23.5 | medicine | the enzyme may have important implications in the pathophysiology and treatment of thrombotic disorders | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.23.5 | 0.0015 | - |
fibrinogen | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.5 | additional information | Homo sapiens | the enzyme may have important implications in the pathophysiology and treatment of thrombotic disorders | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.5 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.23.5 | U-937 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.5 | Fibrin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.23.5 | fibrinogen + H2O | cleaves the alpha-chain, the beta-chain and the gamma-chain | Homo sapiens | low molecular weight fragments of fibrinogen | - |
? | |
| 3.4.23.5 | additional information | the enzyme may have important implications in the pathophysiology and treatment of thrombotic disorders | Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.23.5 | 0.0014 | - |
fibrinogen | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.5 | 3.5 | - |
fibrinogen | Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.5 | 3.5 | 5 | pH 3.5: maximal activity, pH 5.0: about 50% of maximal activity, fibrinogen as substrate | Homo sapiens |
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