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Literature summary extracted from

  • Barnett, J.E.G.; Rasheed, A.; Corina, D.L.
    Partial reactions of D-glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase (1973), Biochem. J., 131, 21-30.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.5.1.4 D-sorbitol 6-phosphate
-
 Rattus norvegicus
5.5.1.4 NaBH4 partial inactivation in presence of NAD+. No inactivation in absence of NAD+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.5.1.4 215000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
5.5.1.4 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
5.5.1.4 D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate formation of 5-keto-D-glucose 6-phosphate as an enzyme-bound intermediate in the conversion of D-glucose 6-phosphate into 1L-myo-inositol 1-phosphate Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.5.1.4 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.5.1.4 D-Glucose 6-phosphate
-
 Rattus norvegicus L-myo-Inositol 1-phosphate
-
 ?
5.5.1.4 additional information after removal of tightly bound NAD+ the enzyme catalyzes the reduction of 5-keto-D-glucitol 6-phosphate and 5-keto-D-glucose 6-phosphate by NADH to give glucitol 6-phosphate and glucose 6-phosphate respectively Rattus norvegicus ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
5.5.1.4 NAD+ tightly bound Rattus norvegicus
5.5.1.4 NAD+ Km: 0.05 mM Rattus norvegicus