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Literature summary extracted from

  • Ghoneim, H.; Klinkert, M.Q.
    Biochemical properties of purified cathepsin B from Schistosoma mansoni (1995), Int. J. Parasitol., 25, 1515-1519.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.1 dithiothreitol activates Schistosoma mansoni

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 benzyloxycarbonyl-Leu-Leu-Tyr-CHN2
-
 Schistosoma mansoni
3.4.22.1 benzyloxycarbonyl-Trp-Met-CHN2
-
 Schistosoma mansoni
3.4.22.1 L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane E-64 Schistosoma mansoni
3.4.22.1 L-trans-epoxysuccinyl-3,5-diiodo-L-tyrosylamido(3-methyl)-butane compound 13b Schistosoma mansoni
3.4.22.1 L-trans-epoxysuccinyl-3,5-diiodo-L-tyrosylamido(3-methyl)-butane ethylester compound 13a Schistosoma mansoni
3.4.22.1 N-(L-3-trans-carboxyoxirane-2-carbonyl)-Ile-Pro CA-030 Schistosoma mansoni
3.4.22.1 N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-Ile-Pro CA-074 Schistosoma mansoni
3.4.22.1 peptidyl diazomethyl ketone derivatives peptidyl diazomethanes Schistosoma mansoni

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.1 0.021
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
-
 Schistosoma mansoni
3.4.22.1 0.041
-
 benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
 Schistosoma mansoni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 Proteins + H2O Schistosoma mansoni
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Schistosoma mansoni
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.1
-
 Schistosoma mansoni

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Schistosoma mansoni benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
-
 Schistosoma mansoni benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 globin + H2O
-
 Schistosoma mansoni partially degraded globin
-
 ?
3.4.22.1 Proteins + H2O
-
 Schistosoma mansoni ?
-
 ?
3.4.22.1 serum albumin + H2O
-
 Schistosoma mansoni partially degraded serum albumin
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.22.1 12.2
-
 benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
-
 Schistosoma mansoni
3.4.22.1 49.5
-
 benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
-
 Schistosoma mansoni

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.1 4 5 globin degradation Schistosoma mansoni