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Literature summary extracted from

  • Lenney, J.F.; Tolan, J.R.; Sugai, W.J.; Lee, A.G.
    Thermostable endogenous inhibitors of cathepsins B and H (1979), Eur. J. Biochem., 101, 153-161.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.16 additional information
-
 Rattus norvegicus
3.4.22.16 additional information activation by autolysis Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 Proteinase inhibitors from rat, human, tuna fish, toad, chicken Rattus norvegicus
3.4.22.16 Thiol proteinase inhibitor proteinase inhibitor from rat, man, hog, Tetrahymena, tuna, chicken, toad, purified rat lung inhibitors have molecular weight of 14000, purified hog kidney inhibitors have molecular weight of 11000, also high molecular weight inhibitors in human and rat serum, tissue distributions in humans and rat: inhibitors widely distributed, probaly regulatory function Homo sapiens
3.4.22.16 Thiol proteinase inhibitor proteinase inhibitor from rat, man, hog, Tetrahymena, tuna, chicken, toad, purified rat lung inhibitors have molecular weight of 14000, purified hog kidney inhibitors have molecular weight of 11000, also high molecular weight inhibitors in human and rat serum, tissue distributions in humans and rat: inhibitors widely distributed, probaly regulatory function Paramecium caudatum
3.4.22.16 Thiol proteinase inhibitor proteinase inhibitor from rat, man, hog, Tetrahymena, tuna, chicken, toad, purified rat lung inhibitors have molecular weight of 14000, purified hog kidney inhibitors have molecular weight of 11000, also high molecular weight inhibitors in human and rat serum, tissue distributions in humans and rat: inhibitors widely distributed, probaly regulatory function Rattus norvegicus
3.4.22.16 Thiol proteinase inhibitor proteinase inhibitor from rat, man, hog, Tetrahymena, tuna, chicken, toad, purified rat lung inhibitors have molecular weight of 14000, purified hog kidney inhibitors have molecular weight of 11000, also high molecular weight inhibitors in human and rat serum, tissue distributions in humans and rat: inhibitors widely distributed, probaly regulatory function Sus scrofa
3.4.22.16 Thiol proteinase inhibitor proteinase inhibitor from rat, man, hog, Tetrahymena, tuna, chicken, toad, purified rat lung inhibitors have molecular weight of 14000, purified hog kidney inhibitors have molecular weight of 11000, also high molecular weight inhibitors in human and rat serum, tissue distributions in humans and rat: inhibitors widely distributed, probaly regulatory function Tetrahymena pyriformis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.1 Proteins + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Rattus norvegicus
-
-
-
3.4.22.16 Homo sapiens
-
-
-
3.4.22.16 Paramecium caudatum
-
-
-
3.4.22.16 Rattus norvegicus
-
-
-
3.4.22.16 Sus scrofa
-
-
-
3.4.22.16 Tetrahymena pyriformis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 liver
-
 Rattus norvegicus
-
3.4.22.16 kidney
-
 Homo sapiens
-
3.4.22.16 kidney
-
 Rattus norvegicus
-
3.4.22.16 kidney
-
 Sus scrofa
-
3.4.22.16 liver
-
 Homo sapiens
-
3.4.22.16 liver
-
 Rattus norvegicus
-
3.4.22.16 spleen
-
 Rattus norvegicus
-
3.4.22.16 spleen
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 benzoyl-DL-Arg-beta-naphthylamide + H2O
-
 Rattus norvegicus benzoyl-DL-Arg + beta-naphthylamine
-
 ?
3.4.22.1 benzoyl-DL-Arg-p-nitroanilide + H2O
-
 Rattus norvegicus benzoyl-DL-Arg + p-nitroaniline
-
 ?
3.4.22.1 Proteins + H2O
-
 Rattus norvegicus ?
-
 ?