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Literature summary extracted from

  • Reid, K.B.M.; Johnson, D.M.A.; Gagnon, J.; Prohaska, R.
    Preparation of human factor D of the alternative pathway of complement (1981), Methods Enzymol., 80, 134-143.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.4.21.46 freezing and thawing causes approximately 30% loss of activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.46 diisopropyl fluorophosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.46 additional information Homo sapiens the enzyme is a component of the alternative pathway of human complement ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.46 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.46
-
 Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.46 additional information
-
 assay methods Homo sapiens

Storage Stability

EC Number Storage Stability Organism
3.4.21.46 -70°C, no aggregation occurs, stable Homo sapiens
3.4.21.46 4°C, 0.1 M Tris-HCl, 0.2 M NaCl, 2 mM EDTA, pH 8.0, 0.02% w/v NaN3, several months, about 10% loss of activity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.46 factor B + H2O cleavage at a single Arg-Lys bond Homo sapiens Bb fragment + Ba fragment
-
 ?
3.4.21.46 additional information the enzyme is a component of the alternative pathway of human complement Homo sapiens ?
-
 ?