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Literature summary extracted from

  • Kalwant, S.; Porter, A.G.
    Purification and characterization of human brain prolyl endopeptidase (1991), Biochem. J., 276, 237-244.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.27 diisopropyl fluorophosphate
-
 Homo sapiens
3.4.21.27 Zn2+ partially Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.27 0.09
-
 benzyloxycarbonyl-Gly-Pro-4-nitroanilide
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.27 79600
-
 1 * 79600, SDS-PAGE Homo sapiens
3.4.21.27 85600
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.27 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.27
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.27 brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.27 2.83
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.27 benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O
-
 Homo sapiens benzyloxycarbonyl-Gly-Pro + 4-nitroaniline
-
 ?
3.4.21.27 benzyloxycarbonyl-Gly-Pro-p-nitroanilide
-
 Homo sapiens benzyloxycarbonyl-Gly-Pro + p-nitroaniline
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.27 monomer 1 * 79600, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.27 6.8
-
-
 Homo sapiens