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Literature summary extracted from

  • Fujikawa, K.; Legaz, M.E.; Kato, H.; Davie, E.W.
    The mechanism of activation of bovine factor IX (Christmas factor) by bovine factor XIa (activated plasma thromboplastin antecedent) (1974), Biochemistry, 13, 4508-4516.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.22 16600
-
 1 * 27300 + 1 * 16600, SDS-PAGE Bos taurus
3.4.21.22 27300
-
 1 * 27300 + 1 * 16600, SDS-PAGE Bos taurus
3.4.21.22 46500
-
 SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.22 factor X + H2O Bos taurus a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa ?
-
 ?
3.4.21.27 factor IX + H2O Bos taurus activation of Factor IX in the intrinsic coagulation cascade ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.22 Bos taurus
-
-
-
3.4.21.27 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.22
-
 Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.22 Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa free of thrombin activity Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Storage Stability

EC Number Storage Stability Organism
3.4.21.22 -20°C, 0.05 M imidazole buffer, pH 6.0, 0.2 M NaCl, no loss of activity after several months Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.22 factor X + H2O a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa Bos taurus ?
-
 ?
3.4.21.22 factor X + H2O
-
 Bos taurus factor Xa
-
 ?
3.4.21.27 factor IX + H2O activation of Factor IX in the intrinsic coagulation cascade Bos taurus ?
-
 ?
3.4.21.27 factor IX + H2O
-
 Bos taurus factor IXa + peptide containing 50% carbohydrate ?

Subunits

EC Number Subunits Comment Organism
3.4.21.22 dimer 1 * 27300 + 1 * 16600, SDS-PAGE Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.4.21.22 activated factor IX
-
 Bos taurus