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Literature summary extracted from

  • Lalu, K.; Lampelo, S.; Vanha-Perttula, T.
    Characterization of three aminopeptidases purified from maternal serum (1986), Biochim. Biophys. Acta, 873, 190-197.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 alanine
-
 Homo sapiens
3.4.11.2 arginine
-
 Homo sapiens
3.4.11.2 EDTA
-
 Homo sapiens
3.4.11.2 epsilon-amino-n-caproic acid 70% inhibition at 100 mM Homo sapiens
3.4.11.2 glutamine
-
 Homo sapiens
3.4.11.2 leucine
-
 Homo sapiens
3.4.11.2 methionine
-
 Homo sapiens
3.4.11.2 puromycin 93% inhibition at 1 mM Homo sapiens
3.4.11.7 EDTA reactivation by Co2+ Homo sapiens
3.4.11.7 L-aspartic acid
-
 Homo sapiens
3.4.11.7 L-Glutamic acid
-
 Homo sapiens
3.4.11.7 puromycin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.11.2 0.054
-
 Lys-2-naphthylamide
-
 Homo sapiens
3.4.11.2 0.068
-
 L-Met-2-naphthylamide
-
 Homo sapiens
3.4.11.2 0.075
-
 L-Arg-2-naphthylamide
-
 Homo sapiens
3.4.11.2 0.095
-
 Leu-2-naphthylamide
-
 Homo sapiens
3.4.11.2 0.117
-
 L-Gln-2-naphthylamide
-
 Homo sapiens
3.4.11.2 0.256
-
 Ala-2-naphthylamide
-
 Homo sapiens
3.4.11.2 0.327
-
 Phe-2-naphthylamide
-
 Homo sapiens
3.4.11.2 0.329
-
 Tyr-2-naphthylamide
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.2 Co2+ increase of activity Homo sapiens
3.4.11.2 Ni2+ reactivation after inhibition by EDTA Homo sapiens
3.4.11.2 Zn2+ reactivation after inhibition by EDTA Homo sapiens
3.4.11.7 Ca2+ activation Homo sapiens
3.4.11.7 Mn2+ activation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.2 aminoacyl peptide Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Homo sapiens
-
-
-
3.4.11.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 intestine
-
 Homo sapiens
-
3.4.11.2 serum
-
 Homo sapiens
-
3.4.11.7 serum maternal and non-maternal Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 Ala-2-naphthylamide + H2O
-
 Homo sapiens Ala + 2-naphthylamine
-
 ?
3.4.11.2 aminoacyl peptide
-
 Homo sapiens ?
-
 ?
3.4.11.2 aminoacyl-2-naphthylamide + H2O
-
 Homo sapiens amino acid + 2-naphthylamine
-
 ?
3.4.11.2 L-Arg-2-naphthylamide + H2O
-
 Homo sapiens L-Arg + 2-naphthylamine
-
 ?
3.4.11.2 L-Gln-2-naphthylamide + H2O
-
 Homo sapiens L-Gln + 2-naphthylamine
-
 ?
3.4.11.2 L-Lys-2-naphthylamide + H2O
-
 Homo sapiens L-Lys + 2-naphthylamine
-
 ?
3.4.11.2 L-Met-2-naphthylamide + H2O
-
 Homo sapiens L-Met + 2-naphthylamine
-
 ?
3.4.11.2 L-Phe-2-naphthylamide + H2O
-
 Homo sapiens L-Phe + 2-naphthylamine
-
 ?
3.4.11.2 L-Tyr-2-naphthylamide + H2O
-
 Homo sapiens L-Tyr + 2-naphthylamine
-
 ?
3.4.11.2 Leu-2-naphthylamide + H2O
-
 Homo sapiens Leu + 2-naphthylamine
-
 ?
3.4.11.7 Asp-beta-naphthylamide + H2O
-
 Homo sapiens Asp + naphthylamine
-
 ?
3.4.11.7 Glu-beta-naphthylamide + H2O
-
 Homo sapiens Glu + naphthylamine
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.11.2 65
-
 60% activity Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.2 6.75 7 substrate Ala-2-naphtylamide Homo sapiens
3.4.11.7 6.75 7.25
-
 Homo sapiens