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Literature summary extracted from
- Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase (1991), Drug Metab. Dispos., 19, 107-112.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.2 | 0.265 | - |
phenyl acetate | pH 7.4, 37°C, type B paraoxonase | Homo sapiens |  |
| 3.1.1.2 | 0.688 | - |
phenyl acetate | pH 7.4, 37°C, type A paraoxonase | Homo sapiens | |
| 3.1.8.1 | 0.271 | - |
paraoxon | pH 7.4, 37°C, type B paraoxonase | Homo sapiens | |
| 3.1.8.1 | 0.503 | - |
paraoxon | pH 7.4, 37°C, type A paraoxonase | Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | NaCl | paraoxonase activity of the B type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase | Homo sapiens | |
| 3.1.8.1 | NaCl | paraoxonase activity of the B type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 43000 | - |
x * 43000, SDS-PAGE | Homo sapiens |
| 3.1.8.1 | 43000 | - |
x * 43000, SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | Homo sapiens | - |
- |
- |
| 3.1.8.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | blood serum | - |
Homo sapiens | - |
| 3.1.8.1 | blood serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.2 | 2-naphthyl acetate + H2O | - |
Homo sapiens | 2-naphthol + acetate | - |
? | |
| 3.1.1.2 | 2-nitrophenyl acetate + H2O | - |
Homo sapiens | 2-nitrophenol + acetate | - |
? | |
| 3.1.1.2 | 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
| 3.1.1.2 | phenyl acetate + H2O | human serum paraoxonase/arylesterase is an esterase with broad substrate specificity. It occurs in two genetically determined allozymic forms, designated types A and B. These allozymes are the products of two allelic genes located at the paraoxonase locus on chromosome 7, which is closely linked to the gene for cystic fibrosis. Paraoxonase activity of the B type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase. The ratio of paraoxonase activity to arylesterase activity of the B-isozyme is about 8, and that of the A isozyme about 1 | Homo sapiens | phenol + acetate | - |
? | |
| 3.1.1.2 | thiophenyl acetate + H2O | - |
Homo sapiens | thiophenol + acetate | - |
? | |
| 3.1.8.1 | paraoxon + H2O | human serum paraoxonase/arylesterase is an esterase with broad substrate specificity. It occurs in two genetically determined allozymic forms, type A and type B. These allozymes are the products of two allelic genes located at the paraoxonase locus on chromosome 7, which is closely linked to the gene for cystic fibrosis. Paraoxonase activity of the B type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase. The ratio of paraoxonase activity to arylesterase activity of the B-isozyme is about 8, and that of the A isozyme about 1 | Homo sapiens | 4-nitrophenol + diethyl phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.2 | ? | x * 43000, SDS-PAGE | Homo sapiens |
| 3.1.8.1 | ? | x * 43000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.2 | paraoxonase/arylesterase | - |
Homo sapiens |
| 3.1.8.1 | high activity paraoxonase | i.e. type B paraoxonase | Homo sapiens |
| 3.1.8.1 | low activity paraoxonase | i.e. type A paraoxonase | Homo sapiens |
| 3.1.8.1 | paraoxonase | - |
Homo sapiens |
| 3.1.8.1 | type A paraoxonase | i.e. low activity paraoxonase | Homo sapiens |
| 3.1.8.1 | type B paraoxonase | i.e. high activity paraoxonase | Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 37 | - |
assay at | Homo sapiens |
| 3.1.8.1 | 37 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.2 | 3373 | - |
phenyl acetate | pH 7.4, 37°C, type B paraoxonase | Homo sapiens | |
| 3.1.1.2 | 4778 | - |
phenyl acetate | pH 7.4, 37°C, type A paraoxonase | Homo sapiens | |
| 3.1.8.1 | 5.7 | - |
paraoxon | pH 7.4, 37°C, type A paraoxonase | Homo sapiens | |
| 3.1.8.1 | 10.98 | - |
paraoxon | pH 7.4, 37°C, type B paraoxonase | Homo sapiens | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 7.4 | - |
assay at | Homo sapiens |
| 3.1.8.1 | 7.4 | - |
assay at | Homo sapiens |
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