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Literature summary extracted from
- Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities (1991), Drug Metab. Dispos., 19, 100-106.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | diisopropylfluorophosphate | competitive inhibition | Homo sapiens |  |
| 3.1.1.2 | EDTA | - |
Homo sapiens | |
| 3.1.1.2 | paraoxon | mixed type inhibition | Homo sapiens | |
| 3.1.1.2 | phenyl acetate | - |
Homo sapiens | |
| 3.1.8.1 | EDTA | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.2 | 0.265 | - |
phenyl acetate | pH 8.0, 25°C, enzyme from phenotype B blood plasma | Homo sapiens | |
| 3.1.1.2 | 0.688 | - |
phenyl acetate | pH 8.0, 25°C, enzyme from phenotype A blood plasma | Homo sapiens | |
| 3.1.8.1 | 0.271 | - |
paraoxon | pH 8.0, 25°C, enzyme from phenotype B blood plasma | Homo sapiens | |
| 3.1.8.1 | 0.503 | - |
paraoxon | pH 8.0, 25°C, enzyme from phenotype A blood plasma | Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | Ca2+ | required | Homo sapiens | |
| 3.1.8.1 | Ca2+ | required | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 43000 | - |
x * 43000, SDS-PAGE | Homo sapiens |
| 3.1.8.1 | 43000 | - |
x * 43000, SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | Homo sapiens | - |
- |
- |
| 3.1.8.1 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.1.2 | glycoprotein | the enzyme has up to three sugar chains per molecule, and carbohydrate represents 15.8% of the total weight | Homo sapiens |
| 3.1.8.1 | glycoprotein | the enzyme has up to three sugar chains per molecule, and carbohydrate represents 15.8% of the total weight | Homo sapiens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.2 | - |
Homo sapiens |
| 3.1.8.1 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | blood serum | of A and B phenotypes. Human serum contains a single enzyme with both paraoxonase and arylesterase activities | Homo sapiens | - |
| 3.1.8.1 | blood serum | of A and B phenotypes. Human serum contains a single enzyme with both paraoxonase and arylesterase activities | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 558 | - |
purified enzyme from phenotype A blood plasma | Homo sapiens |
| 3.1.1.2 | 882 | - |
purified enzyme from phenotype A blood plasma | Homo sapiens |
| 3.1.8.1 | 0.962 | - |
purified enzyme from phenotype A blood plasma | Homo sapiens |
| 3.1.8.1 | 6.64 | - |
purified enzyme from phenotype A blood plasma | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.2 | phenyl acetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
| 3.1.8.1 | paraoxon + H2O | - |
Homo sapiens | 4-nitrophenol + diethylphosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.2 | ? | x * 43000, SDS-PAGE | Homo sapiens |
| 3.1.8.1 | ? | x * 43000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.2 | arylesterase | - |
Homo sapiens |
| 3.1.1.2 | paraoxonase/arylesterase | - |
Homo sapiens |
| 3.1.8.1 | paraoxonase | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 25 | - |
assay at | Homo sapiens |
| 3.1.8.1 | 25 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 8 | - |
assay at | Homo sapiens |
| 3.1.8.1 | 8 | - |
assay at | Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.2 | 0.401 | - |
phenyl acetate | pH 8.0, 25°C, enzyme from phenotype B blood plasma | Homo sapiens | |
| 3.1.1.2 | 0.508 | - |
diisopropylfluorophosphate | pH 8.0, 25°C, enzyme from phenotype B blood plasma | Homo sapiens | |
| 3.1.1.2 | 0.598 | - |
diisopropylfluorophosphate | pH 8.0, 25°C, enzyme from phenotype A blood plasma | Homo sapiens | |
| 3.1.1.2 | 0.885 | - |
phenyl acetate | pH 8.0, 25°C, enzyme from phenotype A blood plasma | Homo sapiens | |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.1.1.2 | Homo sapiens | - |
- |
5.1 |
| 3.1.8.1 | Homo sapiens | - |
- |
5.1 |
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