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Literature summary extracted from
- Reconstitution of the two terminal enzymes of the heme biosynthetic pathway into phospholipid vesicles (1987), J. Biol. Chem., 262, 4407-4412.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.3.4 | phosphatidylcholine | from egg and soybean | Mus musculus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.3.4 | 0.00078 | - |
protoporphyrinogen-IX | in phospholipid vesicles | Mus musculus | |
| 1.3.3.4 | 0.002 | - |
protoporphyrinogen-IX | in detergent solution in presence of cardiolipin | Mus musculus | |
| 1.3.3.4 | 0.0056 | - |
protoporphyrinogen-IX | in detergent solution | Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.98.1.1 | mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | Mus musculus | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 4.98.1.1 | protoporphyrin IX + Fe2+ | Mus musculus | final step of heme biosynthesis | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.3.4 | Mus musculus | - |
- |
- |
| 4.98.1.1 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.3.3.4 | - |
Mus musculus |
| 4.98.1.1 | - |
Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.3.3.4 | liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | - |
Mus musculus | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Mus musculus | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 4.98.1.1 | protoporphyrin IX + Fe2+ | final step of heme biosynthesis | Mus musculus | ? | - |
? | |
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