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Literature summary extracted from

  • Nakagawa, M.; Tsukada, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.
    Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydroxysteroid dehydrogenase activity in mouse kidney (1989), Biochem. J., 106(4), 633-638.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.20 17beta-estradiol
-
 Mus musculus
1.3.1.20 5alpha-Androstan-3-beta-ol-17-one
-
 Mus musculus
1.3.1.20 5alpha-Pregnan-3beta-21-one
-
 Mus musculus
1.3.1.20 5beta-androstan-3beta-ol-17-one
-
 Mus musculus
1.3.1.20 5beta-Pregnan-3beta-ol-20-one
-
 Mus musculus
1.3.1.20 Dienstrol
-
 Mus musculus
1.3.1.20 Hexestrol
-
 Mus musculus
1.3.1.20 Stilbestrol
-
 Mus musculus
1.3.1.20 testosterone
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.20 additional information
-
 additional information
-
 Mus musculus
1.3.1.20 0.67
-
 cis-benzene dihydrodiol NAD+, DD1 Mus musculus
1.3.1.20 0.77
-
 trans-benzene dihydrodiol NADP+, DD1 Mus musculus
1.3.1.20 0.91
-
 cis-benzene dihydrodiol NAD+ Mus musculus
1.3.1.20 1.28
-
 cis-benzene dihydrodiol NADP+, DD3 Mus musculus
1.3.1.20 1.99
-
 cis-benzene dihydrodiol trans-benzene dihydrodiol, NADP+, DD1 Mus musculus
1.3.1.20 6.78
-
 Naphthalene dihydrodiol NADP+ Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.20 cytoplasm
-
 Mus musculus 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.20 39000
-
 1 * 39000, kidney, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.20 additional information Mus musculus metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons ?
-
 ?
1.3.1.20 naphthalene dihydrodiol + NAD(P)+ Mus musculus
-
 ?
-
 ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ Mus musculus
-
 catechol + NAD(P)H
-
 ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ Mus musculus
-
 catechol + NAD(P)H
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.20 Mus musculus
-
 dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
-
1.3.1.20 Mus musculus
-
 enzyme forms: DD1, DD3
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.20 dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein Mus musculus
1.3.1.20 enzyme forms: DD1, DD3 Mus musculus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ isoform DD3 probably identical with 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 and D-xylose dehydrogenase EC 1.1.1.179 Mus musculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.20 adrenal gland low activity Mus musculus
-
1.3.1.20 heart low activity Mus musculus
-
1.3.1.20 kidney
-
 Mus musculus
-
1.3.1.20 liver
-
 Mus musculus
-
1.3.1.20 lung low activity Mus musculus
-
1.3.1.20 testis low activity Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.20 17beta-estradiol + NAD(P)+ isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein Mus musculus ?
-
 ?
1.3.1.20 3-keto steroid + NAD(P)H probably reversible reaction Mus musculus 3alpha-hydroxy steroid + NAD(P)+
-
 ?
1.3.1.20 3alpha-hydroxy steroid + NADP+
-
 Mus musculus 3-keto steroid + NADPH
-
 ?
1.3.1.20 4-nitrobenzaldehyde + NAD(P)H
-
 Mus musculus 4-nitrobenzylalcohol + NAD(P)+
-
 ?
1.3.1.20 alicyclic alcohol + NAD(P)+
-
 Mus musculus ?
-
 ?
1.3.1.20 camphorquinone + NAD(P)H
-
 Mus musculus (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
 ?
1.3.1.20 cis-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Mus musculus catechol + NAD(P)H
-
 r
1.3.1.20 epitestosterone + NAD(P)+ isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein Mus musculus ?
-
 ?
1.3.1.20 glycolithocholic acid + NAD(P)+ NAD+ preferred as cofactor Mus musculus 3-oxo-glycocholanoic acid + NAD(P)H
-
 ?
1.3.1.20 additional information metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons Mus musculus ?
-
 ?
1.3.1.20 additional information NADP+ or NAD+ as cofactors Mus musculus additional information
-
 ?
1.3.1.20 naphthalene dihydrodiol + NAD(P)+
-
 Mus musculus ?
-
 ?
1.3.1.20 tetrahydrodeoxycorticosterone + NAD(P)+ isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein Mus musculus ?
-
 ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Mus musculus catechol + NAD(P)H
-
 ?
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
 Mus musculus catechol + NAD(P)H
-
 r
1.3.1.20 trans-naphthalene dihydrodiol + NAD(P)+
-
 Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.1.20 monomer 1 * 39000, kidney, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
1.3.1.20 DD
-
 Mus musculus
1.3.1.20 dihydrodiol dehydrogenase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.20 25
-
 assay at Mus musculus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.3.1.20 45
-
 dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, 5 min Mus musculus
1.3.1.20 50
-
 dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, all activity lost Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.20 NAD+
-
 Mus musculus
1.3.1.20 NADH
-
 Mus musculus
1.3.1.20 NADP+
-
 Mus musculus