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Literature summary extracted from

  • Tuchman, M.; Roemeling, R.V.; Hrushesky, W.A.M.; Sothern, R.B.; O'Dea, R.F.
    Dihydropyrimidine dehydrogenase activity in human blood mononuclear cells (1989), Enzyme, 42, 15-24.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.2 medicine rate limiting enzyme for detoxification of exogenous fluoropyrimidines, antitumor drug design Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.2 0.001
-
 thymine
-
 Homo sapiens
1.3.1.2 0.01
-
 NADPH
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.2 5-fluorouracil + NADPH + H+ Homo sapiens
-
 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 thymine + NADPH Homo sapiens rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines dihydrothymine + NADP+
-
 ?
1.3.1.2 thymine + NADPH Homo sapiens rate-limiting enzyme of thymidine and uridine degradation dihydrothymine + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 blood
-
 Homo sapiens
-
1.3.1.2 mononuclear cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.2 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 5-fluorouracil + NADPH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 thymine + NADPH
-
 Homo sapiens dihydrothymine + NADP+
-
 ?
1.3.1.2 thymine + NADPH rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines Homo sapiens dihydrothymine + NADP+
-
 ?
1.3.1.2 thymine + NADPH rate-limiting enzyme of thymidine and uridine degradation Homo sapiens dihydrothymine + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 flavin contains 2 mol FMN and 2 mol FAD per mol of enzyme, tightly associated Homo sapiens
1.3.1.2 NADPH
-
 Homo sapiens