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Literature summary extracted from

  • Grisolia, S.; Cardoso, S.S.
    The purification and properties of hydropyrimidine dehydrogenase (1957), Biochim. Biophys. Acta, 25, 430-431.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.2 thymine + NADPH Bos taurus
-
 dihydrothymine + NADP+
-
 r
1.3.1.2 uracil + NADPH Bos taurus
-
 5,6-dihydrouracil + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.2 partial Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.2 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.2 additional information
-
-
 Bos taurus
1.3.1.2 2.2
-
 substrate hydrothymine Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.2 5,6-dihydrouracil + NADP+
-
 Bos taurus uracil + NADPH
-
 r
1.3.1.2 5-bromouracil + NADPH
-
 Bos taurus 5-bromo-5,6-dihydrouracil + NADP+
-
 r
1.3.1.2 5-fluorouracil + NADPH + H+
-
 Bos taurus 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 5-iodouracil + NADPH
-
 Bos taurus 5-iodo-5,6-dihydrouracil + NADP+
-
 r
1.3.1.2 dihydrothymine + NADP+
-
 Bos taurus thymine + NADPH
-
 r
1.3.1.2 hydrouridylic acid + NADPH low activity Bos taurus ?
-
 ?
1.3.1.2 thymine + NADPH
-
 Bos taurus dihydrothymine + NADP+
-
 r
1.3.1.2 uracil + NADPH
-
 Bos taurus 5,6-dihydrouracil + NADP+
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.2 7.4
-
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.2 NADP+
-
 Bos taurus
1.3.1.2 NADPH
-
 Bos taurus