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Literature summary extracted from

  • Pettit, F.H.; Yeaman, S.J.; Reed, L.J.
    Purification and characterization of branched chain alpha-keto acid dehydrogenase complex of bovine kidney (1978), Proc. Natl. Acad. Sci. USA, 75, 4881-4885.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.4 thiamine diphosphate
-
Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.4.4 isobutanoyl-CoA 0.2 mM, 48% inhibition Bos taurus
1.2.4.4 isopentanoyl-CoA 0.2 mM. 56% inhibition Bos taurus
1.2.4.4 NADH
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.4.4 0.037
-
3-methyl-2-oxopentanoate
-
Bos taurus
1.2.4.4 0.04
-
3-methyl-2-oxobutanoate
-
Bos taurus
1.2.4.4 0.05
-
4-methyl-2-oxopentanoate
-
Bos taurus
1.2.4.4 0.056
-
2-oxobutanoate
-
Bos taurus
1.2.4.4 1
-
pyruvate
-
Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.4.4 mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.4.4 additional information Bos taurus regulation by phosphorylation-dephosphorylation ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.4 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.4.4
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.4 kidney
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.4.4 12
-
-
Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.4 2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxobutanoate Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(propanoyl)dihydrolipoyllysine + CO2
-
?
1.2.4.4 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?
1.2.4.4 3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2
-
?
1.2.4.4 4-methyl-2-oxopentanoate + NAD+ + CoA
-
Bos taurus 3-methylbutanoyl-CoA + CO2 + NADH
-
?
1.2.4.4 additional information regulation by phosphorylation-dephosphorylation Bos taurus ?
-
?
1.2.4.4 pyruvate + NAD+ + CoA
-
Bos taurus acetyl-CoA + CO2 + NADH
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.4.4 CoA
-
Bos taurus
1.2.4.4 NAD+
-
Bos taurus