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Literature summary extracted from

  • Rapp, B.J.; Miernyk, J.A.; Randall, D.D.
    Pyruvate dehydrogenase complexes from Ricinus communis endosperm (1987), J. Plant Physiol., 127, 293-306.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.104 acetyl-CoA
-
 Ricinus communis
1.2.1.104 NADH
-
 Ricinus communis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.104 0.003
-
 coenzyme A assay with whole enzyme complex Ricinus communis
1.2.1.104 0.051
-
 NAD+ assay with whole enzyme complex Ricinus communis
1.2.1.104 0.09
-
 pyruvate assay with whole enzyme complex Ricinus communis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.104 mitochondrion
-
 Bos taurus 5739
-
1.2.1.104 mitochondrion
-
 Ricinus communis 5739
-
1.2.1.104 plastid distinct from mitochondrial enzyme, different subunit composition Ricinus communis 9536
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.104 Ca2+
-
 Bos taurus
1.2.1.104 Ca2+ can replace Mg2+ Ricinus communis
1.2.1.104 Mg2+
-
 Ricinus communis
1.2.1.104 Mn2+ can replace Mg2+ Ricinus communis

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Bos taurus
-
-
-
1.2.1.104 Ricinus communis
-
 var. N5
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.104 pyruvate dehydrogenase complex composed of EC 1.2.4.1, EC 2.3.1.12, EC 1.8.1.4 Ricinus communis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.104 endosperm
-
 Ricinus communis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 pyruvate + CoA + NAD+
-
 Ricinus communis acetyl-CoA + CO2 + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.104 additional information
-
-
 Ricinus communis

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 additional information CoA and NAD+ required by pyruvate dehydrogenase complex Ricinus communis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.104 0.015
-
 NADH competitive inhibition vs. NAD+, whole enzyme complex Ricinus communis
1.2.1.104 0.02
-
 acetyl-CoA competitive inhibition vs. CoA, whole enzyme complex Ricinus communis