Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ichihara, K.; Noda, Y.; Tanaka, C.; Kusunose, M.
    Purification of aldehyde dehydrogenase reconstitutively active in fatty alcohol oxidation from rabbit intestinal microsomes (1986), Biochim. Biophys. Acta, 878, 419-425.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 BaCl2 0.1 mM, 10% inhibition of cytosolic enzyme Oryctolagus cuniculus
1.2.1.3 CsCl2 0.1 mM, 19% inhibition of cytosolic enzyme Oryctolagus cuniculus
1.2.1.3 Cu2+ 0.1 mM CuSO4, 7% inhibition of microsomal enzyme, 81% inhibition of the cytosolic enzyme Oryctolagus cuniculus
1.2.1.3 Disulfiram no effect on microsomal enzyme, complete inhibition of the cytosolic enzyme Oryctolagus cuniculus
1.2.1.3 KCl 0.1 mM, 16% inhibition Oryctolagus cuniculus
1.2.1.3 Mg2+ 0.1 mM MgCl2, 63% inhibition of cytosolic enzyme Oryctolagus cuniculus
1.2.1.3 NiCl2 0.1 mM, 24% inhibition of cytosolic enzyme Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.02
-
 dodecanal microsomal enzyme Oryctolagus cuniculus
1.2.1.3 0.035
-
 Heptanal microsomal enzyme Oryctolagus cuniculus
1.2.1.3 0.294
-
 propanal microsomal enzyme Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 cytosol
-
 Oryctolagus cuniculus 5829
-
1.2.1.3 microsome
-
 Oryctolagus cuniculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.3 BaCl2 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus
1.2.1.3 CaCl2 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus
1.2.1.3 CsCl 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus
1.2.1.3 Mg2+ no effect Oryctolagus cuniculus
1.2.1.3 NaCl 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus
1.2.1.3 NiCl2 0.1 mM, slight activation of microsomal enzyme Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.3 additional information
-
 formation of large aggregates in absence of detergent Oryctolagus cuniculus
1.2.1.3 60000
-
 6 * 60000, SDS-PAGE Oryctolagus cuniculus
1.2.1.3 370000
-
 gel filtration in presence of detergents Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3 microsomal enzyme Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 intestine
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.3 8.75
-
 microsomal enzyme Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 acetaldehyde + NAD+ + H2O activity with cytosolic enzyme, no activity with microsomal enzyme Oryctolagus cuniculus acetate + NADH + H+
-
 ?
1.2.1.3 butanal + NAD+ + H2O n-butanal Oryctolagus cuniculus butyrate + NADH + H+
-
 ?
1.2.1.3 decanal + NAD+ + H2O n-decylaldehyde Oryctolagus cuniculus decanoate + NADH
-
 ?
1.2.1.3 dodecanal + NAD+ + H2O n-dodecylaldehyde Oryctolagus cuniculus dodecanoate + NADH
-
 ?
1.2.1.3 formaldehyde + NAD+ + H2O activity with cytosolic enzyme, no activity with microsomal enzyme Oryctolagus cuniculus formate + NADH
-
 ?
1.2.1.3 heptanal + NAD+ + H2O n-heptanal Oryctolagus cuniculus heptanoate + NADH
-
 ?
1.2.1.3 hexanal + NAD+ + H2O n-hexanal Oryctolagus cuniculus hexanoate + NADH + H+
-
 ?
1.2.1.3 n-nonanal + NAD+ + H2O
-
 Oryctolagus cuniculus n-nonanoate + NADH + H+
-
 ?
1.2.1.3 octanal + NAD+ + H2O n-octylaldehyde Oryctolagus cuniculus octanoate + NADH
-
 ?
1.2.1.3 pentanal + NAD+ + H2O n-pentanal Oryctolagus cuniculus pentanoate + NADH
-
 ?
1.2.1.3 propanal + NAD+ + H2O
-
 Oryctolagus cuniculus propionate + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.3 hexamer 6 * 60000, SDS-PAGE Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.3 9
-
 microsomal enzyme Oryctolagus cuniculus
1.2.1.3 9.5 10.5 cytosolic enzyme Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Oryctolagus cuniculus