Literature summary extracted from

Zhou, X.; Cahoon, M.; Rosa, P.; Hedstrom, L.
Expression, purification, and characterization of inosine 5'-monophosphate dehydrogenase from Borrelia burgdorferi (1997), J. Biol. Chem., 35, 21977-21981.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.205	-	Borreliella burgdorferi

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.205	GMP	competitive with respect to IMP	Borreliella burgdorferi
1.1.1.205	Mycophenolic acid	uncompetitive with respect to IMP and NAD+	Borreliella burgdorferi
1.1.1.205	NAD+	substrate inhibition at high concentration	Borreliella burgdorferi
1.1.1.205	thiazole-4-carboxamide adenine dinucleotide	uncompetitive with respect to IMP and NAD	Borreliella burgdorferi
1.1.1.205	xanthosine 5'-phosphate	competitive with respect to IMP	Borreliella burgdorferi

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.1.1.205	additional information	-	additional information	-	Borreliella burgdorferi

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.1.1.205	additional information	-	equilibrium sedimentation results suggest monomeric, dimeric and tetrameric forms and higher order aggregates	Borreliella burgdorferi
1.1.1.205	43640	-	calculated from amino acid composition	Borreliella burgdorferi
1.1.1.205	44000	-	SDS-PAGE	Borreliella burgdorferi

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.205	inosine 5'-phosphate + NAD+ + H2O	Borreliella burgdorferi	subdomain of the enzyme is not required for catalytic activity	xanthosine 5'-phosphate + NADH	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.205	Borreliella burgdorferi	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.205	95% homogeneity	Borreliella burgdorferi

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.1.1.205	0.83	-	-	Borreliella burgdorferi

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.205	inosine 5'-phosphate + NAD+ + H2O	subdomain of the enzyme is not required for catalytic activity	Borreliella burgdorferi	xanthosine 5'-phosphate + NADH	-	?

Turnover Number [1/s]

EC Number	Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1.1.1.205	0.0433	-	NAD+	-	Borreliella burgdorferi

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.1.1.205	additional information	-	additional information	-	Borreliella burgdorferi

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Release 2023.1 (January 2023)