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Mechanism of glutamate semialdehyde aminotransferase roles of diamino- and dioxo-intermediates in the synthesis of aminolevulinate

Pugh, C.E.; Harwood, J.L.; John, R.A.; J. Biol. Chem. 267, 1584-1588 (1992)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.4.3.8
Pisum sativum
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
5.4.3.8
-
Pisum sativum
Reaction
EC Number
Reaction
Commentary
Organism
5.4.3.8
L-glutamate 1-semialdehyde = 5-aminolevulinate
the catalytic mechanism includes enzyme-bound diaminovalerate as a central intermediate
Pisum sativum
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.3.8
leaf
-
Pisum sativum
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.3.8
(S)-4-Amino-5-oxopentanoate
-
3439
Pisum sativum
5-Amino-4-oxopentanoate
-
3439
Pisum sativum
-
5.4.3.8
4,5-Diaminovalerate
is a substrate for the pyridoxal 5'-phosphate form of the enzyme
3439
Pisum sativum
?
-
-
-
-
5.4.3.8
4,5-Dioxovalerate
is a substrate for the pyridoxamine form of the enzyme
3439
Pisum sativum
5-Amino-4-oxopentanoate
-
3439
Pisum sativum
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.4.3.8
pyridoxamine 5'-phosphate
only the pyridoxamine form of the enzyme is active
Pisum sativum
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.4.3.8
pyridoxamine 5'-phosphate
only the pyridoxamine form of the enzyme is active
Pisum sativum
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.4.3.8
-
Pisum sativum
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.3.8
leaf
-
Pisum sativum
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.3.8
(S)-4-Amino-5-oxopentanoate
-
3439
Pisum sativum
5-Amino-4-oxopentanoate
-
3439
Pisum sativum
-
5.4.3.8
4,5-Diaminovalerate
is a substrate for the pyridoxal 5'-phosphate form of the enzyme
3439
Pisum sativum
?
-
-
-
-
5.4.3.8
4,5-Dioxovalerate
is a substrate for the pyridoxamine form of the enzyme
3439
Pisum sativum
5-Amino-4-oxopentanoate
-
3439
Pisum sativum
-