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Literature summary extracted from

  • Babu, B.N.; Brown, O.R.
    Quantitative effects of redox-cycling chemicals on the oxidant-sensitive enzyme dihydroxy-acid dehydratase (1995), Microbios, 82, 157-170.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.1.9 analysis the enzyme is used to quantify and investigate the biological oxidant stress activity of various redox-cycling chemicals. High sensitivity to inactivation by oxidants makes the enzyme useful for identification of compounds which increase oxyradical flux in the cell and for probing their mechanism of action Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.9 3-(5-nitrofuran-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole hydrochloride
-
Escherichia coli
4.2.1.9 benzoquinone
-
Escherichia coli
4.2.1.9 duroquinone
-
Escherichia coli
4.2.1.9 hydralazine
-
Escherichia coli
4.2.1.9 juglone
-
Escherichia coli
4.2.1.9 Nitrofurantoin
-
Escherichia coli
4.2.1.9 paraquat
-
Escherichia coli
4.2.1.9 Plumbagin
-
Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.9 Iron contains a catalytically active [4Fe-4S] cluster Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.9 Escherichia coli
-
K-12
-
4.2.1.9 Escherichia coli
-
CGSC strain 5073
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.9 2,3-dihydroxy-3-methylbutanoate
-
Escherichia coli 2-oxoisovalerate + H2O
-
?
4.2.1.9 2,3-dihydroxy-3-methylpentanoate
-
Escherichia coli 3-methyl-2-oxopentanoate + H2O
-
?