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Literature summary extracted from

  • Couper, L.; McKendrick, J.E.; Robins, D.J.
    Pyridine and piperidine derivatives as inhibitors of dihydrdipicolinic acid synthase, a key enzyme in the diaminopimelate pathway to L-lysine (1994), Bioorg. Med. Chem. Lett., 4, 2267-2272.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.3.7 expression in Escherichia coli Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.3.7 cis-piperidine-2,6-dicarboxylic acid and derivatives Escherichia coli
4.3.3.7 dipicolinic acid 1 mM, 50% inhibition Escherichia coli
4.3.3.7 dipicolinic acid di-imidate
-
 Escherichia coli
4.3.3.7 dipicolinic acid N-oxide 0.8 mM 50% inhibition Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.3.3.7 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.3.7 L-aspartate-4-semialdehyde + pyruvate
-
 Escherichia coli dihydrodipicolinate + H2O
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.3.3.7 0.8
-
 dipicolinic acid N-oxide
-
 Escherichia coli
4.3.3.7 1
-
 dipicolinic acid
-
 Escherichia coli