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Literature summary extracted from
- Regulation of Chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from alcaligenes eutrophus (1976), J. Bacteriol., 126, 723-732.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.51 | L-tyrosine | activation | Cupriavidus necator |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.12 | 4-hydroxyphenylpyruvate | - |
Cupriavidus necator | |
| 1.3.1.12 | coumaric acid | - |
Cupriavidus necator | |
| 1.3.1.12 | dihydroxyphenylalanine | - |
Cupriavidus necator | |
| 1.3.1.12 | L-tyrosine | - |
Cupriavidus necator | |
| 1.3.1.12 | NADH | non-competitive inhibition | Cupriavidus necator | |
| 4.2.1.51 | L-phenylalanine | - |
Cupriavidus necator | |
| 4.2.1.51 | L-tryptophan | - |
Cupriavidus necator | |
| 4.2.1.51 | m-Fluorophenylalanine | - |
Cupriavidus necator | |
| 4.2.1.51 | p-Fluorophenylalanine | - |
Cupriavidus necator | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.12 | 0.045 | 0.09 | prephenate | - |
Cupriavidus necator | |
| 1.3.1.12 | 0.13 | 0.15 | NAD+ | - |
Cupriavidus necator | |
| 4.2.1.51 | 0.67 | - |
prephenate | - |
Cupriavidus necator | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.12 | prephenate + NAD+ | Cupriavidus necator | biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| 4.2.1.51 | prephenate | Cupriavidus necator | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.12 | Cupriavidus necator | - |
- |
- |
| 4.2.1.51 | Cupriavidus necator | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.12 | prephenate + NAD+ | - |
Cupriavidus necator | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| 1.3.1.12 | prephenate + NAD+ | biosynthesis of L-tyrosine | Cupriavidus necator | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| 4.2.1.51 | prephenate | - |
Cupriavidus necator | phenylpyruvate + H2O + CO2 | - |
? | |
| 4.2.1.51 | prephenate | - |
Cupriavidus necator | ? | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.12 | 38 | - |
- |
Cupriavidus necator |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.12 | 7 | 7.6 | - |
Cupriavidus necator |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.12 | 0.06 | - |
L-tyrosine | - |
Cupriavidus necator | |
| 1.3.1.12 | 0.13 | - |
4-hydroxyphenylpyruvate | - |
Cupriavidus necator | |
| 1.3.1.12 | 0.2 | - |
coumaric acid | - |
Cupriavidus necator | |
| 1.3.1.12 | 0.47 | - |
dihydroxyphenylalanine | - |
Cupriavidus necator | |
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