BRENDA - Enzyme Database show

Human CD38 is an authentic NAD(P)+ glycohydrolase

Berthelier, V.; Tixier, J.M.; Muller-Steffner, H.; Schuber, F.; Deterre, P.; Biochem. J. 330, 1383-1390 (1998)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.2.2.6
ADP-ribose
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.2.2.6
0.0016
-
nicotinamide guanine dinucleotide
-
Homo sapiens
3.2.2.6
0.007
-
epsilon-NAD+
-
Homo sapiens
3.2.2.6
0.046
-
beta-NAD+
-
Homo sapiens
3.2.2.6
0.065
-
NADP+
-
Homo sapiens
3.2.2.6
0.224
-
cyclic ADP-ribose
-
Homo sapiens
3.2.2.6
0.851
-
3-acetylpyridine adenine dinucleotide
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.2.2.6
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.2.2.6
leukocyte
the enzyme is the leucocyte antigen CD38
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.2.2.6
3-acetylpyridine adenine dinucleotide + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
alpha-NAD+ + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
beta-NAD+ + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
cyclic ADP-ribose + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
epsilon-NAD+ + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
epsilon-NADP+ + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
additional information
the formation of an enzyme-ADP-ribosyl intermediary complex is common to all reaction pathways
326410
Homo sapiens
?
-
-
-
-
3.2.2.6
NADP+ + H2O
-
326410
Homo sapiens
nicotinamide + ADPribose-phosphate
-
326410
Homo sapiens
?
3.2.2.6
nicotinamide guanine dinucleotide + H2O
-
326410
Homo sapiens
?
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.2.2.6
ADP-ribose
-
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.2.2.6
0.0016
-
nicotinamide guanine dinucleotide
-
Homo sapiens
3.2.2.6
0.007
-
epsilon-NAD+
-
Homo sapiens
3.2.2.6
0.046
-
beta-NAD+
-
Homo sapiens
3.2.2.6
0.065
-
NADP+
-
Homo sapiens
3.2.2.6
0.224
-
cyclic ADP-ribose
-
Homo sapiens
3.2.2.6
0.851
-
3-acetylpyridine adenine dinucleotide
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.2.2.6
leukocyte
the enzyme is the leucocyte antigen CD38
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.2.2.6
3-acetylpyridine adenine dinucleotide + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
alpha-NAD+ + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
beta-NAD+ + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
cyclic ADP-ribose + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
epsilon-NAD+ + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
epsilon-NADP+ + H2O
-
326410
Homo sapiens
?
-
-
-
?
3.2.2.6
additional information
the formation of an enzyme-ADP-ribosyl intermediary complex is common to all reaction pathways
326410
Homo sapiens
?
-
-
-
-
3.2.2.6
NADP+ + H2O
-
326410
Homo sapiens
nicotinamide + ADPribose-phosphate
-
326410
Homo sapiens
?
3.2.2.6
nicotinamide guanine dinucleotide + H2O
-
326410
Homo sapiens
?
-
-
-
?