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Literature summary extracted from

  • Broeker, M.; Schindelmeiser, J.; Pape, H.
    A nicotinamide adenine dinucleotide (phosphate) glycohydrolase [NAD(P)ase, EC 3.2.2.6] from Streptomyces griseus (1979), FEMS Microbiol. Lett., 6, 245-247.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.6 HClO4 5%, 2°C, 10 min, 60% loss of the original activity Streptomyces griseus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.2.6 0.65
-
 NADP+
-
 Streptomyces griseus
3.2.2.6 1.33
-
 NAD+
-
 Streptomyces griseus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.2.6 1600000
-
 gel filtration Streptomyces griseus

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.6 Streptomyces griseus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.2.6 partial Streptomyces griseus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.6 NAD+ + H2O
-
 Streptomyces griseus ADP-D-ribose + nicotinamide
-
 ?
3.2.2.6 NADP+ + H2O
-
 Streptomyces griseus nicotinamide + ADPribose-phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.2.6 56
-
-
 Streptomyces griseus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.2.2.6 60
-
 rapid loss of activity above Streptomyces griseus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.2.6 5.5 8
-
 Streptomyces griseus