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Literature summary extracted from
- Immunoaffinity purification and characterization of thromboxane synthase from porcine lung (1986), J. Biol. Chem., 261, 11592-11599.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.5 | (E)-3-[4-(1-Imidazolylmethyl)phenyl]-2-propenoate | reversible | Sus scrofa |  |
| 5.3.99.5 | 15-hydroperoxyeicosatetraenoic acid | - |
Sus scrofa | |
| 5.3.99.5 | 15-Hydroxy-11alpha,9alpha-(epoxymethano)-prosta-5,13-dienoic acid | reversible | Sus scrofa | |
| 5.3.99.5 | 15-Hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid | irreversible inactivation during catalysis, protection by (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoate and 15-hydroxy-11alpha,9alpha-(epoxymethano)-prosta-5,13-dienoic acid | Sus scrofa | |
| 5.3.99.5 | Cu2+ | 1 mM, complete inhibition | Sus scrofa | |
| 5.3.99.5 | Zn2+ | 1 mM, 50% inhibition | Sus scrofa | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.99.5 | 0.012 | - |
15-hydroxy-9alpha,11alpha-peroxiprosta-5,13-dienoic acid | - |
Sus scrofa | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.5 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.3.99.5 | immunoaffinity purification | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.99.5 | lung | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.5 | 0.231 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.5 | 15-hydroxy-9alpha,11alpha-peroxiprosta-5,13-dienoic acid | - |
Sus scrofa | ? | - |
? | |
| 5.3.99.5 | Prostaglandin H2 | i.e. PGH2 | Sus scrofa | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | the ratio of 12-hydroxy-5,8,10-heptadecatrienoic acid to thromboxane B2 varries from 1.6 to 2.1 depending on the reaction conditions | ? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.5 | 30 | - |
- |
Sus scrofa |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.5 | heme | hemoprotein | Sus scrofa | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.99.5 | 1 | - |
Zn2+ | - |
Sus scrofa | |
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